SH3PXD2A

SH3 and PX domain-containing protein 2A is a protein that in humans is encoded by the SH3PXD2A gene.[5][6]

SH3PXD2A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DNU, 2EGA, 2EGC, 2EKH
Identifiers
Aliases	SH3PXD2A, FISH, SH3MD1, TKS5, SH3 and PX domains 2A
External IDs	MGI: 1298393 HomoloGene: 7317 GeneCards: SH3PXD2A
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q24.33 Start 103,594,027 bp[1] End 103,855,543 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C3 Start 47,260,174 bp[2] End 47,464,401 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • superoxide-generating NADPH oxidase activator activity • phosphatidylinositol binding • protease binding • phosphatidylinositol-4,5-bisphosphate binding • phosphatidylinositol-5-phosphate binding • phosphatidylinositol-3-phosphate binding • phosphatidylinositol-3,4-bisphosphate binding • phosphatidylinositol-4-phosphate binding Cellular component • cytoplasm • podosome • cell junction • cell projection • cytosol Biological process • osteoclast fusion • superoxide metabolic process • reactive oxygen species metabolic process • GO:0048554 positive regulation of catalytic activity • oxidation-reduction process • podosome assembly • extracellular matrix organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9644	14218
Ensembl	ENSG00000107957	ENSMUSG00000053617
UniProt	Q5TCZ1	O89032
RefSeq (mRNA)	NM_014631 NM_001365079	NM_001164717 NM_008018 NM_177833
RefSeq (protein)	NP_055446 NP_001352008	NP_001158189 NP_032044
Location (UCSC)	Chr 10: 103.59 – 103.86 Mb	Chr 19: 47.26 – 47.46 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000107957 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000053617 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lock P, Abram CL, Gibson T, Courtneidge SA (Sep 1998). "A new method for isolating tyrosine kinase substrates used to identify fish, an SH3 and PX domain-containing protein, and Src substrate". EMBO J. 17 (15): 4346–57. doi:10.1093/emboj/17.15.4346. PMC 1170768. PMID 9687503.
6. "Entrez Gene: SH3PXD2A SH3 and PX domains 2A".

Further reading

• Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
• Abram CL, Seals DF, Pass I, et al. (2003). "The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells". J. Biol. Chem. 278 (19): 16844–51. doi:10.1074/jbc.M300267200. PMID 12615925.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Seals DF, Azucena EF, Pass I, et al. (2005). "The adaptor protein Tks5/Fish is required for podosome formation and function, and for the protease-driven invasion of cancer cells". Cancer Cell. 7 (2): 155–65. doi:10.1016/j.ccr.2005.01.006. PMID 15710328.
• Malinin NL, Wright S, Seubert P, et al. (2005). "Amyloid-beta neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity". Proc. Natl. Acad. Sci. U.S.A. 102 (8): 3058–63. doi:10.1073/pnas.0408237102. PMC 549444. PMID 15710903.
• Harold D, Jehu L, Turic D, et al. (2007). "Interaction between the ADAM12 and SH3MD1 genes may confer susceptibility to late-onset Alzheimer's disease". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (4): 448–52. doi:10.1002/ajmg.b.30456. PMID 17440933.