SH3GLB1

Endophilin-B1 is a protein that in humans is encoded by the SH3GLB1 gene.[5][6][7]

SH3GLB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X43
Identifiers
Aliases	SH3GLB1, Bif-1, PPP1R70, dJ612B15.2, CGI-61, SH3 domain containing GRB2 like endophilin B1, SH3 domain containing GRB2 like, endophilin B1
External IDs	OMIM: 609287 MGI: 1859730 HomoloGene: 9337 GeneCards: SH3GLB1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p22.3 Start 86,704,570 bp[1] End 86,748,184 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 H2 Start 144,683,678 bp[2] End 144,720,335 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein homodimerization activity • GO:0001948 protein binding • identical protein binding • lipid binding • cadherin binding Cellular component • cytoplasm • Golgi apparatus • membrane • Golgi membrane • mitochondrial outer membrane • autophagosome membrane • midbody • mitochondrion • extracellular exosome • cytoplasmic vesicle • cytosol Biological process • cellular response to glucose starvation • regulation of cytokinesis • regulation of protein stability • positive regulation of autophagosome assembly • positive regulation of autophagy • positive regulation of protein targeting to mitochondrion • cellular response to amino acid starvation • receptor catabolic process • autophagy • protein oligomerization • membrane fission • positive regulation of protein oligomerization • positive regulation of membrane tubulation • autophagic cell death • regulation of macroautophagy • protein localization to vacuolar membrane • apoptotic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51100	54673
Ensembl	ENSG00000097033	ENSMUSG00000037062
UniProt	Q9Y371	Q9JK48
RefSeq (mRNA)	NM_001206651 NM_001206652 NM_001206653 NM_016009	NM_001282037 NM_001282042 NM_019464 NM_001379170 NM_001379171 NM_001379172 NM_001379173 NM_001379174
RefSeq (protein)	NP_001193580 NP_001193581 NP_001193582 NP_057093	NP_001268966 NP_001268971 NP_062337 NP_001366099 NP_001366100 NP_001366101 NP_001366102 NP_001366103
Location (UCSC)	Chr 1: 86.7 – 86.75 Mb	Chr 3: 144.68 – 144.72 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

SH3GLB1 has been shown to interact with SH3GLB2[5] and Bcl-2-associated X protein.[5][6]

References

1. GRCh38: Ensembl release 89: ENSG00000097033 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037062 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Pierrat B, Simonen M, Cueto M, Mestan J, Ferrigno P, Heim J (February 2001). "SH3GLB, a new endophilin-related protein family featuring an SH3 domain". Genomics. 71 (2): 222–34. doi:10.1006/geno.2000.6378. PMID 11161816.
6. Cuddeback SM, Yamaguchi H, Komatsu K, Miyashita T, Yamada M, Wu C, Singh S, Wang HG (June 2001). "Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax". J Biol Chem. 276 (23): 20559–65. doi:10.1074/jbc.M101527200. PMID 11259440.
7. "Entrez Gene: SH3GLB1 SH3-domain GRB2-like endophilin B1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi:10.1093/dnares/4.5.345. PMID 9455484.
• Howard L, Nelson KK, Maciewicz RA, Blobel CP (1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J. Biol. Chem. 274 (44): 31693–9. doi:10.1074/jbc.274.44.31693. PMID 10531379.
• Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (2000). "Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
• Modregger J, Schmidt AA, Ritter B, Huttner WB, Plomann M (2003). "Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1". J. Biol. Chem. 278 (6): 4160–7. doi:10.1074/jbc.M208568200. PMID 12456676.
• Lee SY, Wenk MR, Kim Y, Nairn AC, De Camilli P (2004). "Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses". Proc. Natl. Acad. Sci. U.S.A. 101 (2): 546–51. doi:10.1073/pnas.0307813100. PMC 327184. PMID 14704270.
• Karbowski M, Jeong SY, Youle RJ (2004). "Endophilin B1 is required for the maintenance of mitochondrial morphology". J. Cell Biol. 166 (7): 1027–39. doi:10.1083/jcb.200407046. PMC 2172012. PMID 15452144.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Takahashi Y, Karbowski M, Yamaguchi H, Kazi A, Wu J, Sebti SM, Youle RJ, Wang HG (2005). "Loss of Bif-1 Suppresses Bax/Bak Conformational Change and Mitochondrial Apoptosis". Mol. Cell. Biol. 25 (21): 9369–82. doi:10.1128/MCB.25.21.9369-9382.2005. PMC 1265816. PMID 16227588.
• Masuda M, Takeda S, Sone M, Ohki T, Mori H, Kamioka Y, Mochizuki N (2006). "Endophilin BAR domain drives membrane curvature by two newly identified structure-based mechanisms". EMBO J. 25 (12): 2889–97. doi:10.1038/sj.emboj.7601176. PMC 1500852. PMID 16763557.
• Lee JW, Jeong EG, Soung YH, Nam SW, Lee JY, Yoo NJ, Lee SH (2006). "Decreased expression of tumour suppressor Bax-interacting factor-1 (Bif-1), a Bax activator, in gastric carcinomas". Pathology. 38 (4): 312–5. doi:10.1080/00313020600820880. PMID 16916719.