SH3BP5

SH3 domain-binding protein 5 is a protein that in humans is encoded by the SH3BP5 gene.[5][6][7]

SH3BP5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4H3B
Identifiers
Aliases	SH3BP5, SAB, SH3BP-5, SH3 domain binding protein 5
External IDs	OMIM: 605612 MGI: 1344391 HomoloGene: 23450 GeneCards: SH3BP5
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p25.1 Start 15,254,353 bp[1] End 15,341,368 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 B Start 31,359,880 bp[2] End 31,436,078 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein kinase inhibitor activity • GO:0001948 protein binding • SH3 domain binding • Rab guanyl-nucleotide exchange factor activity • guanyl-nucleotide exchange factor activity Cellular component • cytoplasm • mitochondrion • nucleoplasm • nuclear body • cytoplasmic vesicle membrane • membrane • cytoplasmic vesicle Biological process • signal transduction • negative regulation of protein tyrosine kinase activity • GO:0007243 intracellular signal transduction • negative regulation of protein kinase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9467	24056
Ensembl	ENSG00000131370	ENSMUSG00000021892
UniProt	O60239	Q9Z131
RefSeq (mRNA)	NM_001018009 NM_004844	NM_011894 NM_001347585
RefSeq (protein)	NP_001018009 NP_004835	NP_001334514 NP_036024
Location (UCSC)	Chr 3: 15.25 – 15.34 Mb	Chr 14: 31.36 – 31.44 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

SH3BP5 has been shown to interact with Bruton's tyrosine kinase[5][6] and MAPK8.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000131370 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021892 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Matsushita M; Yamadori T; Kato S; Takemoto Y; Inazawa J; Baba Y; Hashimoto S; Sekine S; Arai S; Kunikata T; Kurimoto M; Kishimoto T; Tsukada S (June 1998). "Identification and characterization of a novel SH3-domain binding protein, Sab, which preferentially associates with Bruton's tyrosine kinase (BtK)". Biochem Biophys Res Commun. 245 (2): 337–43. doi:10.1006/bbrc.1998.8420. PMID 9571151.
6. Yamadori T; Baba Y; Matsushita M; Hashimoto S; Kurosaki M; Kurosaki T; Kishimoto T; Tsukada S (June 1999). "Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein". Proc Natl Acad Sci U S A. 96 (11): 6341–6. Bibcode:1999PNAS...96.6341Y. doi:10.1073/pnas.96.11.6341. PMC 26883. PMID 10339589.
7. "Entrez Gene: SH3BP5 SH3-domain binding protein 5 (BTK-associated)".
8. Wiltshire, Carolyn; Matsushita Masato; Tsukada Satoshi; Gillespie David A F; May Gerhard H W (November 2002). "A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria". Biochem. J. England. 367 (Pt 3): 577–85. doi:10.1042/BJ20020553. ISSN 0264-6021. PMC 1222945. PMID 12167088.

Further reading

• Baba Y, Matsushita M, Matsuda Y, et al. (2000). "Assignment of SH3BP5/Sh3bp5 encoding sab, an SH3 domain-binding protein which preferentially associates with Bruton's tyrosine kinase, to human chromosome 1q43 and mouse chromosome 14B by in situ hybridization". Cytogenet. Cell Genet. 87 (3–4): 221–2. doi:10.1159/000015430. PMID 10702676.
• Wiltshire C, Matsushita M, Tsukada S, et al. (2002). "A new c-Jun N-terminal kinase (JNK)-interacting protein, Sab (SH3BP5), associates with mitochondria". Biochem. J. 367 (Pt 3): 577–85. doi:10.1042/BJ20020553. PMC 1222945. PMID 12167088.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Court NW; Kuo I; Quigley O; Bogoyevitch MA (2004). "Phosphorylation of the mitochondrial protein Sab by stress-activated protein kinase 3". Biochem. Biophys. Res. Commun. 319 (1): 130–7. doi:10.1016/j.bbrc.2004.04.148. PMID 15158451.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiltshire C; Gillespie DA; May GH (2005). "Sab (SH3BP5), a novel mitochondria-localized JNK-interacting protein". Biochem. Soc. Trans. 32 (Pt 6): 1075–7. doi:10.1042/BST0321075. PMID 15506969.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.