SH2D3A

SH2 domain-containing protein 3A is a protein that in humans is encoded by the SH2D3A gene.[3][4] The protein may be useful in Western Blots and ELISAs.[5]

SH2D3A
Identifiers
Aliases	SH2D3A, NSP1, SH2 domain containing 3A
External IDs	OMIM: 604721 HomoloGene: 48351 GeneCards: SH2D3A
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 6,752,160 bp[1] End 6,767,463 bp[1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • guanyl-nucleotide exchange factor activity Cellular component • intracellular Biological process • small GTPase mediated signal transduction • JNK cascade • positive regulation of signal transduction • positive regulation of peptidyl-serine phosphorylation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10045	n/a
Ensembl	ENSG00000125731	n/a
UniProt	Q9BRG2	n/a
RefSeq (mRNA)	NM_005490	n/a
RefSeq (protein)	NP_005481	n/a
Location (UCSC)	Chr 19: 6.75 – 6.77 Mb	n/a
PubMed search	[2]	n/a
Wikidata
View/Edit Human

Interactions

SH2D3A has been shown to interact with the epidermal growth factor receptor.[3] The gene may play a role in JNK activation.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000125731 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Lu Y, Brush J, Stewart TA (Apr 1999). "NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway". The Journal of Biological Chemistry. 274 (15): 10047–52. doi:10.1074/jbc.274.15.10047. PMID 10187783.
4. "Entrez Gene: SH2D3A SH2 domain containing 3A".
5. "Recombinant Human SH2D3A Protein". potassium-channel. Potassium Channel. 1 August 2017. Retrieved 18 September 2017.
6. "SH2D3A Gene". genecards.org. Gene Cards. Retrieved 18 September 2017.

Further reading

• Near RI, Zhang Y, Makkinje A, Vanden Borre P, Lerner A (Sep 2007). "AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology". Journal of Cellular Physiology. 212 (3): 655–65. doi:10.1002/jcp.21059. PMC 2640322. PMID 17427198.
• Vervoort VS, Roselli S, Oshima RG, Pasquale EB (Apr 2007). "Splice variants and expression patterns of SHEP1, BCAR3 and NSP1, a gene family involved in integrin and receptor tyrosine kinase signaling". Gene. 391 (1–2): 161–70. doi:10.1016/j.gene.2006.12.016. PMC 1876674. PMID 17270363.
• Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (Jun 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Molecular & Cellular Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

External links

• SH2D3A human gene location in the UCSC Genome Browser.
• SH2D3A human gene details in the UCSC Genome Browser.