SH2D1B

SH2 domain-containing protein 1B is a protein that in humans is encoded by the SH2D1B gene.[5][6][7]

SH2D1B
Identifiers
Aliases	SH2D1B, EAT2, SH2 domain containing 1B
External IDs	OMIM: 608510 MGI: 1349420 HomoloGene: 8070 GeneCards: SH2D1B
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 162,395,268 bp[1] End 162,412,138 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H3 Start 170,277,320 bp[2] End 170,286,769 bp[2]
Gene ontology Molecular function • protein binding, bridging • GO:0001948 protein binding Cellular component • cytosol • intracellular Biological process • innate immune system • leukocyte activation involved in immune response • adaptive immune response • positive regulation of natural killer cell mediated immunity • positive regulation of innate immune response • regulation of immune response • immune system process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	117157	26904
Ensembl	ENSG00000198574	ENSMUSG00000102418
UniProt	O14796	O35324 Q149T1
RefSeq (mRNA)	NM_053282	NM_012009
RefSeq (protein)	NP_444512	NP_036139
Location (UCSC)	Chr 1: 162.4 – 162.41 Mb	Chr 1: 170.28 – 170.29 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001).[supplied by OMIM][7]

Interactions

SH2D1B has been shown to interact with SLAMF1.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000198574 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000102418 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Thompson AD, Braun BS, Arvand A, Stewart SD, May WA, Chen E, Korenberg J, Denny C (Feb 1997). "EAT-2 is a novel SH2 domain containing protein that is up regulated by Ewing's sarcoma EWS/FLI1 fusion gene". Oncogene. 13 (12): 2649–58. PMID 9000139.
6. Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C (Nov 2001). "Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells". EMBO J. 20 (21): 5840–52. doi:10.1093/emboj/20.21.5840. PMC 125701. PMID 11689425.
7. "Entrez Gene: SH2D1B SH2 domain containing 1B".

Further reading

• Morra M, Howie D, Grande MS, et al. (2001). "X-linked lymphoproliferative disease: a progressive immunodeficiency". Annu. Rev. Immunol. 19: 657–82. doi:10.1146/annurev.immunol.19.1.657. PMID 11244050.
• Veillette A, Latour S (2004). "The SLAM family of immune-cell receptors". Curr. Opin. Immunol. 15 (3): 277–85. doi:10.1016/S0952-7915(03)00041-4. PMID 12787752.
• Tangye SG, van de Weerdt BC, Avery DT, Hodgkin PD (2002). "CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2". Eur. J. Immunol. 32 (6): 1640–9. doi:10.1002/1521-4141(200206)32:6<1640::AID-IMMU1640>3.0.CO;2-S. PMID 12115647.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Eissmann P, Watzl C (2006). "Molecular analysis of NTB-A signaling: a role for EAT-2 in NTB-A-mediated activation of human NK cells". J. Immunol. 177 (5): 3170–7. doi:10.4049/jimmunol.177.5.3170. PMID 16920955.