SGIP1

SH3-containing GRB2-like protein 3-interacting protein 1 is a protein that in humans is encoded by the SGIP1 gene.[5][6]

SGIP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5AWR, 5AWT, 5AWU, 5AWS
Identifiers
Aliases	SGIP1, SH3 domain GRB2 like endophilin interacting protein 1, SH3GL interacting endocytic adaptor 1
External IDs	OMIM: 611540 MGI: 1920344 HomoloGene: 13001 GeneCards: SGIP1
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p31.3 Start 66,533,383 bp[1] End 66,751,139 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 C6 Start 102,741,297 bp[2] End 102,973,628 bp[2]
Gene ontology Molecular function • microtubule binding • SH3 domain binding • tubulin binding • GO:0001948 protein binding • phospholipid binding • cytoskeletal protein binding Cellular component • cytoplasm • cell membrane • clathrin-coated pit • AP-2 adaptor complex • membrane • clathrin-coated vesicle • cytosol • cytoskeleton Biological process • positive regulation of receptor-mediated endocytosis • endocytosis • plasma membrane tubulation • membrane organization • response to dietary excess • positive regulation of feeding behavior • clathrin-dependent endocytosis • energy homeostasis • clathrin coat assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84251	73094
Ensembl	ENSG00000118473	ENSMUSG00000028524
UniProt	Q9BQI5	Q8VD37
RefSeq (mRNA)	NM_001308203 NM_032291 NM_001350217 NM_001350218 NM_001376534 NM_001376535 NM_001376536 NM_001376537 NM_001376538 NM_001376539 NM_001376540 NM_001376541 NM_001376542 NM_001376543 NM_001376544 NM_001376545 NM_001376546 NM_001376547 NM_001376548 NM_001376549 NM_001376550 NM_001376551 NM_001376552 NM_001376554 NM_001376555 NM_001376556 NM_001376557	NM_001285852 NM_001285859 NM_001285860 NM_001285862 NM_144906
RefSeq (protein)	NP_001295132 NP_115667 NP_001337146 NP_001337147 NP_001363463 NP_001363464 NP_001363465 NP_001363466 NP_001363467 NP_001363468 NP_001363469 NP_001363470 NP_001363471 NP_001363472 NP_001363473 NP_001363474 NP_001363475 NP_001363476 NP_001363477 NP_001363478 NP_001363479 NP_001363480 NP_001363481 NP_001363483 NP_001363484 NP_001363485 NP_001363486	NP_001272781 NP_001272788 NP_001272789 NP_001272791 NP_659155
Location (UCSC)	Chr 1: 66.53 – 66.75 Mb	Chr 4: 102.74 – 102.97 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000118473 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028524 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
6. "Entrez Gene: SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Trevaskis J, Walder K, Foletta V, et al. (2005). "Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance". Endocrinology. 146 (9): 3757–64. doi:10.1210/en.2005-0282. PMID 15919751.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Uezu A, Horiuchi A, Kanda K, et al. (2007). "SGIP1alpha is an endocytic protein that directly interacts with phospholipids and Eps15". J. Biol. Chem. 282 (36): 26481–9. doi:10.1074/jbc.M703815200. PMID 17626015.