SFXN1

Sideroflexin-1 is a protein that in humans is encoded by the SFXN1 gene.[5] According to Nora Kory et al., SFXN1 gene product has mitochondrial serine transporter activity[6].

SFXN1
Identifiers
Aliases	SFXN1, TCC, sideroflexin 1, SLC56A1
External IDs	OMIM: 615569 MGI: 2137677 HomoloGene: 41494 GeneCards: SFXN1
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q35.2 Start 175,477,062 bp[1] End 175,529,742 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 B1|13 28.4 cM Start 54,071,869 bp[2] End 54,108,342 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • ion transmembrane transporter activity • L-serine transmembrane transporter activity • D-serine transmembrane transporter activity Cellular component • integral component of membrane • membrane • mitochondrion • mitochondrial membranes • integral component of mitochondrial inner membrane • mitochondrial inner membrane Biological process • erythrocyte differentiation • ion transmembrane transport • iron ion homeostasis • iron ion transport • ion transport • transmembrane transport • one-carbon metabolic process • L-serine transport • D-serine transport • serine import into mitochondrion • amino acid transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	94081	14057
Ensembl	ENSG00000164466	ENSMUSG00000021474
UniProt	Q9H9B4	Q99JR1
RefSeq (mRNA)	NM_022754 NM_001322977 NM_001322978 NM_001322980 NM_001322981 NM_001322982 NM_001322983	NM_027324
RefSeq (protein)	NP_001309906 NP_001309907 NP_001309909 NP_001309910 NP_001309911 NP_001309912 NP_073591	NP_081600
Location (UCSC)	Chr 5: 175.48 – 175.53 Mb	Chr 13: 54.07 – 54.11 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000164466 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021474 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: SFXN1 sideroflexin 1".
6. Kory N, Wyant GA, Prakash G, Uit de Bos J, Bottanelli F, Pacold ME, et al. (November 2018). "SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism". Science. 362 (6416): eaat9528. doi:10.1126/science.aat9528. PMC 6300058. PMID 30442778.

Further reading

• Kaplan RS, Mayor JA (October 1993). "Structure, function and regulation of the tricarboxylate transport protein from rat liver mitochondria". Journal of Bioenergetics and Biomembranes. 25 (5): 503–14. doi:10.1007/BF01108407. PMID 8132490.
• Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, et al. (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Fleming MD, Campagna DR, Haslett JN, Trenor CC, Andrews NC (March 2001). "A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice". Genes & Development. 15 (6): 652–7. doi:10.1101/gad.873001. PMC 312659. PMID 11274051.
• Zara V, Giudetti AM, Siculella L, Palmieri F, Gnoni GV (November 2001). "Covariance of tricarboxylate carrier activity and lipogenesis in liver of polyunsaturated fatty acid (n-6) fed rats". European Journal of Biochemistry. 268 (22): 5734–9. doi:10.1046/j.0014-2956.2001.02508.x. PMID 11722557.
• Miyake S, Yamashita T, Taniguchi M, Tamatani M, Sato K, Tohyama M (July 2002). "Identification and characterization of a novel mitochondrial tricarboxylate carrier". Biochemical and Biophysical Research Communications. 295 (2): 463–8. doi:10.1016/S0006-291X(02)00694-0. PMID 12150972.
• Giudetti AM, Sabetta S, di Summa R, Leo M, Damiano F, Siculella L, Gnoni GV (November 2003). "Differential effects of coconut oil- and fish oil-enriched diets on tricarboxylate carrier in rat liver mitochondria". Journal of Lipid Research. 44 (11): 2135–41. doi:10.1194/jlr.M300237-JLR200. PMID 14634051.
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, et al. (February 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Siculella L, Damiano F, Sabetta S, Gnoni GV (July 2004). "n-6 PUFAs downregulate expression of the tricarboxylate carrier in rat liver by transcriptional and posttranscriptional mechanisms". Journal of Lipid Research. 45 (7): 1333–40. doi:10.1194/jlr.M400061-JLR200. PMID 15060089.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, et al. (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Siculella L, Sabetta S, Damiano F, Giudetti AM, Gnoni GV (December 2004). "Different dietary fatty acids have dissimilar effects on activity and gene expression of mitochondrial tricarboxylate carrier in rat liver". FEBS Letters. 578 (3): 280–4. doi:10.1016/j.febslet.2004.11.014. PMID 15589833.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, et al. (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.