SFRS11

SRSF11
Identifiers
Aliases	SRSF11, NET2, SFRS11, dJ677H15.2, p54, serine/arginine-rich splicing factor 11, serine and arginine rich splicing factor 11
External IDs	OMIM: 602010 MGI: 1916457 HomoloGene: 36164 GeneCards: SRSF11
Gene location (Human)
Chr.	Chromosome 1 (human)[1]
End	70,253,052 bp[1]
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)[2]
End	158,036,639 bp[2]
RNA expression pattern
	; ;
	More reference expression data
Gene ontology
Molecular function	• GO:0001948 protein binding; • nucleic acid binding; • RNA binding;
Cellular component	• cell nucleus; • nucleoplasm; • nuclear speck;
Biological process	• mRNA splicing, via spliceosome; • termination of RNA polymerase II transcription; • mRNA processing; • mRNA 3'-end processing; • mRNA export from nucleus; • RNA splicing; • RNA export from nucleus;
	Sources:Amigo / QuickGO
Orthologs
	9295
	69207
	ENSG00000116754
	ENSMUSG00000055436
	Q05519; Q5T757
	n/a
NM_001190987; NM_004768; NM_001350605; NM_001350606; NM_001350607;
	NM_001350608; NM_001350609; NM_001350610; NM_001350611; NM_001350612; NM_001350613; NM_001350614; NM_001350615; NM_001350616
	NM_001093752; NM_001093753; NM_026989; NM_001356997
NP_001177916; NP_004759; NP_001337534; NP_001337535; NP_001337536;
	NP_001337537; NP_001337538; NP_001337539; NP_001337540; NP_001337541; NP_001337542; NP_001337543; NP_001337544; NP_001337545
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Splicing factor, arginine/serine-rich 11 is a protein that in humans is encoded by the SFRS11 gene.[5][6]

This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may play a role in pre-mRNA processing.[6]

Interactions

SFRS11 has been shown to interact with U2AF2.[7]

gollark: ```"You mean that a program designed to let an unprivileged usermount/unmount/eject anything he wants has a security flaw because it allowshim to mount/unmount/eject anything he wants? I'm shocked."Unfortunately, sarcasm does not make you right. Yes, this is a critical security flaw, because anyone with calibre installed on their system now allows any user to gain root privileges by mounting on top of important directories. Just because your application allows this by design rather than by mistake doesn't make this less of a problem.```

gollark: Er, has.

gollark: Didn't it make its own SUID disk mounting thing which had several major bugs?

gollark: Yes, that.

gollark: * inferior

References

GRCh38: Ensembl release 89: ENSG00000116754 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000055436 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Chaudhary N; McMahon C; Blobel G (October 1991). "Primary structure of a human arginine-rich nuclear protein that colocalizes with spliceosome components". Proc Natl Acad Sci U S A. 88 (18): 8189–93. Bibcode:1991PNAS...88.8189C. doi:10.1073/pnas.88.18.8189. PMC 52472. PMID 1896467.
"Entrez Gene: SFRS11 splicing factor, arginine/serine-rich 11".
Zhang, W J; Wu J Y (October 1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing". Mol. Cell. Biol. UNITED STATES. 16 (10): 5400–8. doi:10.1128/MCB.16.10.5400. ISSN 0270-7306. PMC 231539. PMID 8816452.

Zhang WJ; Wu JY (1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing". Mol. Cell. Biol. 16 (10): 5400–8. doi:10.1128/MCB.16.10.5400. PMC 231539. PMID 8816452.
Straub T, Grue P, Uhse A, et al. (1998). "The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction". J. Biol. Chem. 273 (41): 26261–4. doi:10.1074/jbc.273.41.26261. PMID 9756848.
Page-McCaw PS; Amonlirdviman K; Sharp PA (2000). "PUF60: a novel U2AF65-related splicing activity". RNA. 5 (12): 1548–60. doi:10.1017/S1355838299991938. PMC 1369877. PMID 10606266.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Sakashita E, Tatsumi S, Werner D, et al. (2004). "Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo". Mol. Cell. Biol. 24 (3): 1174–87. doi:10.1128/MCB.24.3.1174-1187.2004. PMC 321435. PMID 14729963.
Wu JY, Kar A, Kuo D, et al. (2006). "SRp54 (SFRS11), a regulator for tau exon 10 alternative splicing identified by an expression cloning strategy". Mol. Cell. Biol. 26 (18): 6739–47. doi:10.1128/MCB.00739-06. PMC 1592875. PMID 16943417.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116754 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000055436 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1896467-5] Chaudhary N; McMahon C; Blobel G (October 1991). "Primary structure of a human arginine-rich nuclear protein that colocalizes with spliceosome components". Proc Natl Acad Sci U S A. 88 (18): 8189–93. Bibcode:1991PNAS...88.8189C. doi:10.1073/pnas.88.18.8189. PMC 52472. PMID 1896467.

[entrez-6] "Entrez Gene: SFRS11 splicing factor, arginine/serine-rich 11".

[pmid8816452-7] Zhang, W J; Wu J Y (October 1996). "Functional properties of p54, a novel SR protein active in constitutive and alternative splicing". Mol. Cell. Biol. UNITED STATES. 16 (10): 5400–8. doi:10.1128/MCB.16.10.5400. ISSN 0270-7306. PMC 231539. PMID 8816452.

SFRS11

Interactions

References

Further reading