SESN1

Sestrin 1, also known as p53-regulated protein PA26, is a protein that in humans is encoded by the SESN1 gene. This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.[5][6][7]

SESN1
Identifiers
Aliases	SESN1, PA26, SEST1, sestrin 1
External IDs	OMIM: 606103 MGI: 2155278 HomoloGene: 8697 GeneCards: SESN1
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q21 Start 108,986,437 bp[1] End 109,094,819 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 B2|10 22.77 cM Start 41,809,935 bp[2] End 41,908,424 bp[2]
Gene ontology Molecular function • oxidoreductase activity • peroxiredoxin activity • GO:0001948 protein binding • leucine binding • oxidoreductase activity, acting on peroxide as acceptor Cellular component • cytosol • cytoplasm • GATOR2 complex • cell nucleus • fibrillar center • TORC2 complex Biological process • regulation of response to reactive oxygen species • oxidation-reduction process • reactive oxygen species metabolic process • cellular oxidant detoxification • negative regulation of TORC1 signaling • cellular response to amino acid starvation • cellular response to glucose starvation • positive regulation of macroautophagy • cellular response to amino acid stimulus • cellular response to leucine • cellular response to leucine starvation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	27244	140742
Ensembl	ENSG00000080546	ENSMUSG00000038332
UniProt	Q9Y6P5	P58006
RefSeq (mRNA)	NM_014454 NM_001199933 NM_001199934	NM_001013370 NM_001162908
RefSeq (protein)	NP_001186862 NP_001186863 NP_055269	NP_001013388 NP_001156380
Location (UCSC)	Chr 6: 108.99 – 109.09 Mb	Chr 10: 41.81 – 41.91 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

See also

• SESN2

References

1. GRCh38: Ensembl release 89: ENSG00000080546 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038332 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: sestrin 1".
6. Buckbinder L, Talbott R, Seizinger BR, Kley N (October 1994). "Gene regulation by temperature-sensitive p53 mutants: identification of p53 response genes". Proceedings of the National Academy of Sciences of the United States of America. 91 (22): 10640–4. doi:10.1073/pnas.91.22.10640. PMC 45077. PMID 7938006.
7. Velasco-Miguel S, Buckbinder L, Jean P, Gelbert L, Talbott R, Laidlaw J, Seizinger B, Kley N (January 1999). "PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes". Oncogene. 18 (1): 127–37. doi:10.1038/sj.onc.1202274. PMID 9926927.

Further reading

• Budanov AV, Sablina AA, Feinstein E, Koonin EV, Chumakov PM (April 2004). "Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD". Science. 304 (5670): 596–600. doi:10.1126/science.1095569. PMID 15105503.
• Peeters H, Debeer P, Bairoch A, Wilquet V, Huysmans C, Parthoens E, Fryns JP, Gewillig M, Nakamura Y, Niikawa N, Van de Ven W, Devriendt K (May 2003). "PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse". Human Genetics. 112 (5–6): 573–80. doi:10.1007/s00439-003-0917-5. PMID 12607115.