SEPX1

Methionine-R-sulfoxide reductase B1 is an enzyme that in humans is encoded by the SEPX1 gene.[5][6]

MSRB1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMSRB1, SELR, SELX, SEPX1, SepR, HSPC270, methionine sulfoxide reductase B1
External IDsOMIM: 606216 MGI: 1351642 HomoloGene: 8455 GeneCards: MSRB1
Gene location (Human)
Chr.Chromosome 16 (human)[1]
Band16p13.3Start1,938,210 bp[1]
End1,943,326 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

51734

27361

Ensembl

ENSG00000198736

ENSMUSG00000075705

UniProt

Q9NZV6

Q9JLC3

RefSeq (mRNA)

NM_016332
NM_001382264
NM_001382265

NM_013759
NM_001346668

RefSeq (protein)

NP_057416
NP_001369193
NP_001369194

NP_001333597
NP_038787

Location (UCSC)Chr 16: 1.94 – 1.94 MbChr 17: 24.74 – 24.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein belongs to the methionine sulfoxide reductase B (MsrB) family, and it is expressed in a variety of adult and fetal tissues.[6]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000198736 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000075705 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Lescure A, Gautheret D, Carbon P, Krol A (Feb 2000). "Novel selenoproteins identified in silico and in vivo by using a conserved RNA structural motif". J Biol Chem. 274 (53): 38147–54. doi:10.1074/jbc.274.53.38147. PMID 10608886.
  6. "Entrez Gene: SEPX1 selenoprotein X, 1".

Further reading


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