SEPT10

Septin 10 is a protein that in humans is encoded by the SEPT10 gene.[5]

SEPTIN10
Identifiers
Aliases	SEPTIN10, septin 10, SEPT10
External IDs	OMIM: 611737 MGI: 1918110 HomoloGene: 27035 GeneCards: SEPTIN10
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q13 Start 109,542,799 bp[1] End 109,614,143 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B4 Start 59,141,627 bp[2] End 59,221,847 bp[2]
Gene ontology Molecular function • nucleotide binding • GTP binding • GO:0001948 protein binding • GTPase activity • GO:0032947 molecular adaptor activity Cellular component • cytoplasm • cytoskeleton • septin ring • microtubule cytoskeleton • septin complex • septin filament array Biological process • cell cycle • cell division • mitotic cytokinesis • septin ring assembly • cilium morphogenesis • cytoskeleton-dependent cytokinesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	151011	103080
Ensembl	ENSG00000186522	ENSMUSG00000019917
UniProt	Q9P0V9	Q8C650
RefSeq (mRNA)	NM_144710 NM_178584 NM_001321496 NM_001321498 NM_001321499 NM_001321500 NM_001321501 NM_001321502 NM_001321503 NM_001321504 NM_001321505 NM_001321506 NM_001321507 NM_001321508 NM_001321509 NM_001321510 NM_001321511 NM_001321512 NM_001321513 NM_001321514 NM_001321515	NM_001024910 NM_001024911
RefSeq (protein)	NP_001308425 NP_001308427 NP_001308428 NP_001308429 NP_001308430 NP_001308431 NP_001308432 NP_001308433 NP_001308434 NP_001308435 NP_001308436 NP_001308437 NP_001308438 NP_001308439 NP_001308440 NP_001308441 NP_001308442 NP_001308443 NP_001308444 NP_653311 NP_848699 NP_001308427.1	NP_001020081 NP_001020082 NP_001365992 NP_001365993 NP_001365994 NP_001365995
Location (UCSC)	Chr 2: 109.54 – 109.61 Mb	Chr 10: 59.14 – 59.22 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the septin family of cytoskeletal proteins with GTPase activity. This protein localizes to the cytoplasm and nucleus and displays GTP-binding and GTPase activity. Alternative splicing results in multiple transcript variants.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000186522 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019917 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Septin 10".

Further reading

• Sui L, Zhang W, Liu Q, Chen T, Li N, Wan T, Yu M, Cao X (May 2003). "Cloning and functional characterization of human septin 10, a novel member of septin family cloned from dendritic cells". Biochemical and Biophysical Research Communications. 304 (2): 393–8. doi:10.1016/s0006-291x(03)00601-6. PMID 12711328.
• Benedetti D, Bomben R, Dal-Bo M, Marconi D, Zucchetto A, Degan M, Forconi F, Del-Poeta G, Gaidano G, Gattei V (January 2008). "Are surrogates of IGHV gene mutational status useful in B-cell chronic lymphocytic leukemia? The example of Septin-10". Leukemia. 22 (1): 224–6. doi:10.1038/sj.leu.2404867. PMID 17657217.
• Xu M, Takanashi M, Oikawa K, Nishi H, Isaka K, Yoshimoto T, Ohyashiki J, Kuroda M (April 2012). "Identification of a novel role of Septin 10 in paclitaxel-resistance in cancers through a functional genomics screen". Cancer Science. 103 (4): 821–7. doi:10.1111/j.1349-7006.2012.02221.x. PMID 22320903.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.