SEPSECS

O-phosphoseryl-tRNA(Sec) selenium transferase is an enzyme that in humans is encoded by the SEPSECS gene.[5][6][7][8][9]

SEPSECS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3HL2, 4ZDO, 4ZDL, 4ZDP
Identifiers
Aliases	SEPSECS, LP, PCH2D, SLA, SLA/LP, Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase, soluble liver antigen
External IDs	OMIM: 613009 MGI: 1098791 HomoloGene: 15031 GeneCards: SEPSECS
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p15.2 Start 25,120,014 bp[1] End 25,160,449 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 C1|5 28.44 cM Start 52,640,087 bp[2] End 52,669,708 bp[2]
Gene ontology Molecular function • transferase activity • tRNA binding • transferase activity, transferring selenium-containing groups • catalytic activity • GO:0001948 protein binding • RNA binding • phosphoseryl-selenocysteinyl-tRNA selenium transferase activity Cellular component • cytoplasm • cytosol • cell nucleus Biological process • selenocysteine incorporation • protein biosynthesis • selenocysteine metabolic process • selenocysteinyl-tRNA(Sec) biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51091	211006
Ensembl	ENSG00000109618	ENSMUSG00000029173
UniProt	Q9HD40	Q6P6M7
RefSeq (mRNA)	NM_001159728 NM_016955	NM_172490 NM_001363463
RefSeq (protein)	NP_058651	NP_766078 NP_001350392
Location (UCSC)	Chr 4: 25.12 – 25.16 Mb	Chr 5: 52.64 – 52.67 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000109618 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029173 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Xu XM, Mix H, Carlson BA, Grabowski PJ, Gladyshev VN, Berry MJ, Hatfield DL (Dec 2005). "Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery". J. Biol. Chem. 280 (50): 41568–75. doi:10.1074/jbc.M506696200. PMID 16230358.
6. Costa M, Rodríguez-Sánchez JL, Czaja AJ, Gelpí C (Aug 2000). "Isolation and characterization of cDNA encoding the antigenic protein of the human tRNP(Ser)Sec complex recognized by autoantibodies from patients with type-1 autoimmune hepatitis". Clin. Exp. Immunol. 121 (2): 364–74. doi:10.1046/j.1365-2249.2000.01280.x. PMC 1905695. PMID 10931155.
7. Yuan J, Palioura S, Salazar JC, Su D, O'Donoghue P, Hohn MJ, Cardoso AM, Whitman WB, Söll D (Dec 2006). "RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea". Proc. Natl. Acad. Sci. U.S.A. 103 (50): 18923–7. doi:10.1073/pnas.0609703104. PMC 1748153. PMID 17142313.
8. Xu XM, Carlson BA, Mix H, Zhang Y, Saira K, Glass RS, Berry MJ, Gladyshev VN, Hatfield DL (Apr 2007). "Biosynthesis of selenocysteine on its tRNA in eukaryotes". PLoS Biol. 5 (1): e4. doi:10.1371/journal.pbio.0050004. PMC 1717018. PMID 17194211.
9. "Entrez Gene: SLA/LP soluble liver antigen/liver pancreas antigen".

Further reading

• Herkel J, Heidrich B, Nieraad N, Wies I, Rother M, Lohse AW (2002). "Fine specificity of autoantibodies to soluble liver antigen and liver/pancreas". Hepatology. 35 (2): 403–8. doi:10.1053/jhep.2002.30699. PMID 11826415.
• Volkmann M, Martin L, Bäurle A, Heid H, Strassburg CP, Trautwein C, Fiehn W, Manns MP (2001). "Soluble liver antigen: isolation of a 35-kd recombinant protein (SLA-p35) specifically recognizing sera from patients with autoimmune hepatitis". Hepatology. 33 (3): 591–6. doi:10.1053/jhep.2001.22218. PMID 11230739.
• Wies I, Brunner S, Henninger J, Herkel J, Kanzler S, Meyer zum Büschenfelde KH, Lohse AW (2000). "Identification of target antigen for SLA/LP autoantibodies in autoimmune hepatitis". Lancet. 355 (9214): 1510–5. doi:10.1016/S0140-6736(00)02166-8. PMID 10801173.