SEMA6C

Semaphorin-6C is a protein that in humans is encoded by the SEMA6C gene.[5][6]

SEMA6C
Identifiers
Aliases	SEMA6C, SEMAY, m-SemaY, m-SemaY2, semaphorin 6C
External IDs	OMIM: 609294 MGI: 1338032 HomoloGene: 7931 GeneCards: SEMA6C
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 151,131,685 bp[1] End 151,146,664 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.1 Start 95,160,457 bp[2] End 95,174,024 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • semaphorin receptor binding • chemorepellent activity • neuropilin binding Cellular component • integral component of membrane • cell membrane • membrane • integral component of plasma membrane • cytoplasm • cell surface • extracellular Biological process • multicellular organism development • cell differentiation • nervous system development • axon guidance • negative regulation of axon extension • neural crest cell migration • positive regulation of cell migration • negative regulation of axon extension involved in axon guidance • negative chemotaxis • semaphorin-plexin signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10500	20360
Ensembl	ENSG00000143434	ENSMUSG00000038777
UniProt	Q9H3T2	Q9WTM3
RefSeq (mRNA)	NM_001178061 NM_001178062 NM_030913	NM_001272024 NM_011351
RefSeq (protein)	NP_001171532 NP_001171533 NP_112175	NP_001258953 NP_035481
Location (UCSC)	Chr 1: 151.13 – 151.15 Mb	Chr 3: 95.16 – 95.17 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene product is a member of the semaphoring family of proteins. Semaphorins represent important molecular signals controlling multiple aspects of the cellular response that follows CNS injury, and thus may play an important role in neural regeneration.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000143434 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038777 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Qu X, Wei H, Zhai Y, Que H, Chen Q, Tang F, Wu Y, Xing G, Zhu Y, Liu S, Fan M, He F (Sep 2002). "Identification, characterization, and functional study of the two novel human members of the semaphorin gene family". J Biol Chem. 277 (38): 35574–85. doi:10.1074/jbc.M206451200. PMID 12110693.
6. "Entrez Gene: SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C".

Further reading

• Pasterkamp RJ, Verhaagen J (2001). "Emerging roles for semaphorins in neural regeneration". Brain Res. Brain Res. Rev. 35 (1): 36–54. doi:10.1016/S0165-0173(00)00050-3. PMID 11245885.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Imabayashi H, Mori T, Gojo S, et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Exp. Cell Res. 288 (1): 35–50. doi:10.1016/S0014-4827(03)00130-7. PMID 12878157.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.