SEMA5A

Semaphorin-5A is a protein that in humans is encoded by the SEMA5A gene.[5][6][7]

SEMA5A
Identifiers
Aliases	SEMA5A, SEMAF, semF, semaphorin 5A
External IDs	OMIM: 609297 MGI: 107556 HomoloGene: 2949 GeneCards: SEMA5A
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p15.31 Start 9,035,033 bp[1] End 9,546,075 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 B3.1|15 13.02 cM Start 32,244,810 bp[2] End 32,696,341 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • chondroitin sulfate proteoglycan binding • heparan sulfate proteoglycan binding • syndecan binding • semaphorin receptor binding • neuropilin binding • chemorepellent activity Cellular component • membrane • cell membrane • extracellular exosome • integral component of membrane • extracellular Biological process • negative regulation of endothelial cell apoptotic process • negative regulation of cell adhesion • cell differentiation • positive regulation of protein kinase B signaling • positive regulation of endothelial cell proliferation • positive regulation of endothelial cell chemotaxis • cell-cell signaling • positive regulation of axon extension involved in axon guidance • blood vessel endothelial cell proliferation involved in sprouting angiogenesis • nervous system development • positive regulation of angiogenesis • multicellular organism development • diencephalon development • cell adhesion • signal clustering • cell chemotaxis • positive chemotaxis • axonal fasciculation • positive regulation of actin filament depolymerization • negative regulation of axon extension involved in axon guidance • negative chemotaxis • neural crest cell migration • positive regulation of cell migration • semaphorin-plexin signaling pathway • positive regulation of canonical Wnt signaling pathway • axon extension • neuron projection guidance Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9037	20356
Ensembl	ENSG00000112902	ENSMUSG00000022231
UniProt	Q13591	Q62217 Q3UPZ0
RefSeq (mRNA)	NM_003966	NM_009154
RefSeq (protein)	NP_003957	NP_033180
Location (UCSC)	Chr 5: 9.04 – 9.55 Mb	Chr 15: 32.24 – 32.7 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Members of the semaphorin protein family, such as SEMA5A, are involved in axonal guidance during neural development (Adams et al., 1996).[supplied by OMIM][7]

Semaphorine 5A also plays a role in autism, reducing the ability of neurons to form connections with other neurons in certain brain regions (Mosca-Boidron et al 2016).

References

1. GRCh38: Ensembl release 89: ENSG00000112902 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022231 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Adams RH, Betz H, Puschel AW (Feb 1997). "A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis". Mech Dev. 57 (1): 33–45. doi:10.1016/0925-4773(96)00525-4. PMID 8817451.
6. Simmons AD, Puschel AW, McPherson JD, Overhauser J, Lovett M (Mar 1998). "Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval". Biochem Biophys Res Commun. 242 (3): 685–91. doi:10.1006/bbrc.1997.8027. PMID 9464278.
7. "Entrez Gene: SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Simmons AD, Overhauser J, Lovett M (1997). "Isolation of cDNAs from the Cri-du-chat critical region by direct screening of a chromosome 5-specific cDNA library". Genome Res. 7 (2): 118–27. doi:10.1101/gr.7.2.118. PMID 9049630.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Artigiani S, Conrotto P, Fazzari P, et al. (2005). "Plexin-B3 is a functional receptor for semaphorin 5A". EMBO Rep. 5 (7): 710–4. doi:10.1038/sj.embor.7400189. PMC 1299100. PMID 15218527.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Schmutz J, Martin J, Terry A, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5". Nature. 431 (7006): 268–74. doi:10.1038/nature02919. PMID 15372022.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Melin M, Carlsson B, Anckarsater H, et al. (2007). "Constitutional downregulation of SEMA5A expression in autism". Neuropsychobiology. 54 (1): 64–9. doi:10.1159/000096040. PMC 2553518. PMID 17028446.