SEMA4C

Semaphorin-4C is a protein that in humans is encoded by the SEMA4C gene.[5][6]

SEMA4C
Identifiers
Aliases	SEMA4C, M-SEMA-F, SEMACL1, SEMAF, SEMAI, semaphorin 4C
External IDs	OMIM: 604462 MGI: 109252 HomoloGene: 23047 GeneCards: SEMA4C
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q11.2 Start 96,859,718 bp[1] End 96,870,757 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 B Start 36,548,639 bp[2] End 36,558,349 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • neuropilin binding • semaphorin receptor binding • chemorepellent activity Cellular component • integral component of membrane • postsynaptic membrane • GO:0097483, GO:0097481 postsynaptic density • cell membrane • synapse • synaptic vesicle membrane • cell junction • cytoplasmic vesicle • extracellular • membrane • integral component of plasma membrane Biological process • cell differentiation • cell migration in hindbrain • cerebellum development • nervous system development • multicellular organism development • muscle cell differentiation • neural tube closure • positive regulation of stress-activated MAPK cascade • semaphorin-plexin signaling pathway • negative chemotaxis • neural crest cell migration • positive regulation of cell migration • negative regulation of axon extension involved in axon guidance Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54910	20353
Ensembl	ENSG00000168758	ENSMUSG00000026121
UniProt	Q9C0C4	Q64151
RefSeq (mRNA)	NM_017789	NM_001126047 NM_001304329 NM_001304330
RefSeq (protein)	NP_060259	NP_001119519 NP_001291258 NP_001291259
Location (UCSC)	Chr 2: 96.86 – 96.87 Mb	Chr 1: 36.55 – 36.56 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

SEMA4C has been shown to interact with DLG4.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000168758 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026121 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Inagaki S, Furuyama T, Iwahashi Y (October 1995). "Identification of a member of mouse semaphorin family". FEBS Lett. 370 (3): 269–72. doi:10.1016/0014-5793(95)00850-9. PMID 7656991.
6. "Entrez Gene: SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C".
7. Inagaki S, Ohoka Y, Sugimoto H, Fujioka S, Amazaki M, Kurinami H, Miyazaki N, Tohyama M, Furuyama T (March 2001). "Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95". J. Biol. Chem. 276 (12): 9174–81. doi:10.1074/jbc.M009051200. PMID 11134026.

Further reading

• Simmons AD, Püschel AW, McPherson JD, Overhauser J, Lovett M (1998). "Molecular cloning and mapping of human semaphorin F from the Cri-du-chat candidate interval". Biochem. Biophys. Res. Commun. 242 (3): 685–91. doi:10.1006/bbrc.1997.8027. PMID 9464278.
• Wang LH, Kalb RG, Strittmatter SM (1999). "A PDZ protein regulates the distribution of the transmembrane semaphorin, M-SemF". J. Biol. Chem. 274 (20): 14137–46. doi:10.1074/jbc.274.20.14137. PMID 10318831.
• Inagaki S, Ohoka Y, Sugimoto H, Fujioka S, Amazaki M, Kurinami H, Miyazaki N, Tohyama M, Furuyama T (2001). "Sema4c, a transmembrane semaphorin, interacts with a post-synaptic density protein, PSD-95". J. Biol. Chem. 276 (12): 9174–81. doi:10.1074/jbc.M009051200. PMID 11134026.
• Ohoka Y, Hirotani M, Sugimoto H, Fujioka S, Furuyama T, Inagaki S (2001). "Semaphorin 4C, a transmembrane semaphorin, [corrected] associates with a neurite-outgrowth-related protein, SFAP75". Biochem. Biophys. Res. Commun. 280 (1): 237–43. doi:10.1006/bbrc.2000.4080. PMID 11162505.
• Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.