SEMA4B

Semaphorin-4B is a protein that in humans is encoded by the SEMA4B gene.[5][6]

SEMA4B
Identifiers
Aliases	SEMA4B, SEMAC, SemC, semaphorin 4B
External IDs	OMIM: 617029 MGI: 107559 HomoloGene: 8426 GeneCards: SEMA4B
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q26.1 Start 90,160,604 bp[1] End 90,229,679 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 D2 Start 80,186,841 bp[2] End 80,226,527 bp[2]
Gene ontology Molecular function • neuropilin binding • semaphorin receptor binding • chemorepellent activity Cellular component • integral component of membrane • membrane • extracellular • cell membrane • integral component of plasma membrane Biological process • multicellular organism development • cell differentiation • nervous system development • negative chemotaxis • neural crest cell migration • positive regulation of cell migration • negative regulation of axon extension involved in axon guidance • semaphorin-plexin signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10509	20352
Ensembl	ENSG00000185033	ENSMUSG00000030539
UniProt	Q9NPR2	Q62179
RefSeq (mRNA)	NM_020210 NM_198925 NM_001324029 NM_001324030 NM_001324031 NM_001324032 NM_001324033 NM_001324034	NM_013659 NM_001360135
RefSeq (protein)	NP_001310958 NP_001310959 NP_001310960 NP_001310961 NP_001310962 NP_001310963 NP_064595 NP_945119	NP_038687 NP_001347064
Location (UCSC)	Chr 15: 90.16 – 90.23 Mb	Chr 7: 80.19 – 80.23 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000185033 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030539 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Puschel AW, Adams RH, Betz H (Jun 1995). "Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension". Neuron. 14 (5): 941–8. doi:10.1016/0896-6273(95)90332-1. PMID 7748561.
6. "Entrez Gene: SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B".

Further reading

• Nagase T, Kikuno R, Hattori A, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
• Swiercz JM, Kuner R, Behrens J, Offermanns S (2002). "Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology". Neuron. 35 (1): 51–63. doi:10.1016/S0896-6273(02)00750-X. PMID 12123608.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.