SEMA3C

Semaphorin-3C is a protein that in humans is encoded by the SEMA3C gene.[5][6][7]

SEMA3C
Identifiers
Aliases	SEMA3C, SEMAE, SemE, semaphorin 3C
External IDs	OMIM: 602645 MGI: 107557 HomoloGene: 36201 GeneCards: SEMA3C
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q21.11 Start 80,742,538 bp[1] End 80,922,359 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 A3 Start 17,574,281 bp[2] End 17,730,268 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • semaphorin receptor binding • neuropilin binding • chemorepellent activity Cellular component • extracellular region • extracellular exosome • extracellular • integral component of plasma membrane Biological process • somitogenesis • cell differentiation • limb bud formation • outflow tract morphogenesis • post-embryonic development • nervous system development • axon guidance • multicellular organism development • heart development • blood vessel remodeling • pulmonary myocardium development • immune response • neural tube development • dichotomous subdivision of terminal units involved in salivary gland branching • cardiac right ventricle morphogenesis • response to drug • neural crest cell migration • negative chemotaxis • outflow tract septum morphogenesis • semaphorin-plexin signaling pathway • cardiac endothelial to mesenchymal transition • positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis • positive regulation of cell migration • negative regulation of axon extension involved in axon guidance Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10512	20348
Ensembl	ENSG00000075223	ENSMUSG00000028780
UniProt	Q99985	Q62181
RefSeq (mRNA)	NM_006379 NM_001350120 NM_001350121	NM_013657
RefSeq (protein)	NP_006370 NP_001337049 NP_001337050	NP_038685
Location (UCSC)	Chr 7: 80.74 – 80.92 Mb	Chr 5: 17.57 – 17.73 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000075223 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028780 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Püschel AW, Adams RH, Betz H (May 1995). "Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension". Neuron. 14 (5): 941–8. doi:10.1016/0896-6273(95)90332-1. PMID 7748561.
6. Mangasser-Stephan K, Dooley S, Welter C, Mutschler W, Hanselmann RG (May 1997). "Identification of human semaphorin E gene expression in rheumatoid synovial cells by mRNA differential display". Biochemical and Biophysical Research Communications. 234 (1): 153–6. doi:10.1006/bbrc.1997.6607. PMID 9168980.
7. "Entrez Gene: SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C".

Further reading

• Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC (September 1994). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics. 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
• Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Chen H, Chédotal A, He Z, Goodman CS, Tessier-Lavigne M (September 1997). "Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III". Neuron. 19 (3): 547–59. doi:10.1016/S0896-6273(00)80371-2. PMID 9331348.
• Yamada T, Endo R, Gotoh M, Hirohashi S (December 1997). "Identification of semaphorin E as a non-MDR drug resistance gene of human cancers". Proceedings of the National Academy of Sciences of the United States of America. 94 (26): 14713–8. doi:10.1073/pnas.94.26.14713. PMC 25101. PMID 9405678.
• Galani E, Sgouros J, Petropoulou C, Janinis J, Aravantinos G, Dionysiou-Asteriou D, Skarlos D, Gonos E (2002). "Correlation of MDR-1, nm23-H1 and H Sema E gene expression with histopathological findings and clinical outcome in ovarian and breast cancer patients". Anticancer Research. 22 (4): 2275–80. PMID 12174914.
• Rieger J, Wick W, Weller M (June 2003). "Human malignant glioma cells express semaphorins and their receptors, neuropilins and plexins". Glia. 42 (4): 379–89. doi:10.1002/glia.10210. PMID 12730958.
• Miller LE, Weidler C, Falk W, Angele P, Schaumburger J, Schölmerich J, Straub RH (April 2004). "Increased prevalence of semaphorin 3C, a repellent of sympathetic nerve fibers, in the synovial tissue of patients with rheumatoid arthritis". Arthritis and Rheumatism. 50 (4): 1156–63. doi:10.1002/art.20110. PMID 15077297.
• Beckers J, Herrmann F, Rieger S, Drobyshev AL, Horsch M, Hrabé de Angelis M, Seliger B (April 2005). "Identification and validation of novel ERBB2 (HER2, NEU) targets including genes involved in angiogenesis". International Journal of Cancer. 114 (4): 590–7. doi:10.1002/ijc.20798. PMID 15609325.
• Herman JG, Meadows GG (May 2007). "Increased class 3 semaphorin expression modulates the invasive and adhesive properties of prostate cancer cells". International Journal of Oncology. 30 (5): 1231–8. doi:10.3892/ijo.30.5.1231. PMID 17390026.