SEMA3B

Semaphorin-3B is a protein that in humans is encoded by the SEMA3B gene.[5][6][7]

SEMA3B
Identifiers
Aliases	SEMA3B, LUCA-1, SEMA5, SEMAA, SemA, semaV, semaphorin 3B
External IDs	OMIM: 601281 MGI: 107561 HomoloGene: 20972 GeneCards: SEMA3B
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 50,267,558 bp[1] End 50,277,546 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F1|9 58.31 cM Start 107,597,674 bp[2] End 107,609,229 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • neuropilin binding • semaphorin receptor binding • chemorepellent activity Cellular component • extracellular region • endoplasmic reticulum • extracellular • integral component of plasma membrane • collagen-containing extracellular matrix Biological process • axon guidance • cell-cell signaling • negative chemotaxis • neural crest cell migration • positive regulation of cell migration • negative regulation of axon extension involved in axon guidance • chemorepulsion of axon • semaphorin-plexin signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7869	20347
Ensembl	ENSG00000012171	ENSMUSG00000057969
UniProt	Q13214	Q62177
RefSeq (mRNA)	NM_001005914 NM_001290060 NM_001290061 NM_001290062 NM_001290063 NM_004636	NM_001042779 NM_001291537 NM_001291538 NM_001291539 NM_009153
RefSeq (protein)	NP_001005914 NP_001276989 NP_001276990 NP_001276991 NP_001276992 NP_004627	n/a
Location (UCSC)	Chr 3: 50.27 – 50.28 Mb	Chr 9: 107.6 – 107.61 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The semaphorin/collapsin family of molecules plays a critical role in the guidance of growth cones during neuronal development. The secreted protein encoded by this gene family member is important in axonal guidance and has been shown to act as a tumor suppressor by inducing apoptosis.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000012171 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000057969 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Püschel AW, Adams RH, Betz H (May 1995). "Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension". Neuron. 14 (5): 941–8. doi:10.1016/0896-6273(95)90332-1. PMID 7748561.
6. Sekido Y, Bader S, Latif F, Chen JY, Duh FM, Wei MH, Albanesi JP, Lee CC, Lerman MI, Minna JD (April 1996). "Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns". Proceedings of the National Academy of Sciences of the United States of America. 93 (9): 4120–5. doi:10.1073/pnas.93.9.4120. PMC 39497. PMID 8633026.
7. "Entrez Gene: SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B".

Further reading

• Wei MH, Latif F, Bader S, Kashuba V, Chen JY, Duh FM, Sekido Y, Lee CC, Geil L, Kuzmin I, Zabarovsky E, Klein G, Zbar B, Minna JD, Lerman MI (April 1996). "Construction of a 600-kilobase cosmid clone contig and generation of a transcriptional map surrounding the lung cancer tumor suppressor gene (TSG) locus on human chromosome 3p21.3: progress toward the isolation of a lung cancer TSG". Cancer Research. 56 (7): 1487–92. PMID 8603390.
• Takahashi T, Nakamura F, Jin Z, Kalb RG, Strittmatter SM (October 1998). "Semaphorins A and E act as antagonists of neuropilin-1 and agonists of neuropilin-2 receptors". Nature Neuroscience. 1 (6): 487–93. doi:10.1038/2203. PMID 10196546.
• Lerman MI, Minna JD (November 2000). "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Research. 60 (21): 6116–33. PMID 11085536.
• Tomizawa Y, Sekido Y, Kondo M, Gao B, Yokota J, Roche J, Drabkin H, Lerman MI, Gazdar AF, Minna JD (November 2001). "Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B". Proceedings of the National Academy of Sciences of the United States of America. 98 (24): 13954–9. doi:10.1073/pnas.231490898. PMC 61148. PMID 11717452.
• Tse C, Xiang RH, Bracht T, Naylor SL (January 2002). "Human Semaphorin 3B (SEMA3B) located at chromosome 3p21.3 suppresses tumor formation in an adenocarcinoma cell line". Cancer Research. 62 (2): 542–6. PMID 11809707.
• Ochi K, Mori T, Toyama Y, Nakamura Y, Arakawa H (2002). "Identification of semaphorin3B as a direct target of p53". Neoplasia. 4 (1): 82–7. doi:10.1038/sj.neo.7900211. PMC 1503310. PMID 11922394.
• Kuroki T, Trapasso F, Yendamuri S, Matsuyama A, Alder H, Williams NN, Kaiser LR, Croce CM (June 2003). "Allelic loss on chromosome 3p21.3 and promoter hypermethylation of semaphorin 3B in non-small cell lung cancer". Cancer Research. 63 (12): 3352–5. PMID 12810670.
• Castro-Rivera E, Ran S, Thorpe P, Minna JD (August 2004). "Semaphorin 3B (SEMA3B) induces apoptosis in lung and breast cancer, whereas VEGF165 antagonizes this effect". Proceedings of the National Academy of Sciences of the United States of America. 101 (31): 11432–7. doi:10.1073/pnas.0403969101. PMC 509218. PMID 15273288.
• Marsit CJ, Wiencke JK, Liu M, Kelsey KT (August 2005). "The race associated allele of Semaphorin 3B (SEMA3B) T415I and its role in lung cancer in African-Americans and Latino-Americans". Carcinogenesis. 26 (8): 1446–9. doi:10.1093/carcin/bgi098. PMID 15831529.
• Nair PN, McArdle L, Cornell J, Cohn SL, Stallings RL (April 2007). "High-resolution analysis of 3p deletion in neuroblastoma and differential methylation of the SEMA3B tumor suppressor gene". Cancer Genetics and Cytogenetics. 174 (2): 100–10. doi:10.1016/j.cancergencyto.2006.11.017. PMID 17452250.