SEC22A

Vesicle-trafficking protein SEC22a is a protein that in humans is encoded by the SEC22A gene.[5][6][7]

SEC22A
Identifiers
Aliases	SEC22A, SEC22L2, SEC22 homolog A, vesicle trafficking protein
External IDs	OMIM: 612442 MGI: 2447876 HomoloGene: 8246 GeneCards: SEC22A
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q21.1 Start 123,201,927 bp[1] End 123,274,136 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B3 Start 35,311,131 bp[2] End 35,363,918 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • SNAP receptor activity • GO:0001948 protein binding • SNARE binding • transporter activity Cellular component • integral component of membrane • endoplasmic reticulum membrane • endoplasmic reticulum • membrane • SNARE complex Biological process • protein transport • vesicle-mediated transport • vesicle fusion with Golgi apparatus • exocytosis • ER to Golgi vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	26984	317717
Ensembl	ENSG00000121542	ENSMUSG00000034473
UniProt	Q96IW7	Q8BH47
RefSeq (mRNA)	NM_012430	NM_133704
RefSeq (protein)	NP_036562	NP_598465
Location (UCSC)	Chr 3: 123.2 – 123.27 Mb	Chr 16: 35.31 – 35.36 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene belongs to the member of the SEC22 family of vesicle trafficking proteins. This protein has similarity to rat SEC22 and may act in the early stages of the secretory pathway. There is evidence for the use of multiple poly A sites in this gene.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000121542 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034473 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hay JC, Chao DS, Kuo CS, Scheller RH (Apr 1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell. 89 (1): 149–58. doi:10.1016/S0092-8674(00)80191-9. PMID 9094723.
6. Tang BL, Low DY, Hong W (Mar 1998). "Hsec22c: a homolog of yeast Sec22p and mammalian rsec22a and msec22b/ERS-24". Biochem Biophys Res Commun. 243 (3): 885–91. doi:10.1006/bbrc.1998.8194. PMID 9501016.
7. "Entrez Gene: SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae)".

Further reading

• Hay JC, Hirling H, Scheller RH (1996). "Mammalian vesicle trafficking proteins of the endoplasmic reticulum and Golgi apparatus". J. Biol. Chem. 271 (10): 5671–9. doi:10.1074/jbc.271.10.5671. PMID 8621431.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Mancias JD, Goldberg J (2007). "The transport signal on Sec22 for packaging into COPII-coated vesicles is a conformational epitope". Mol. Cell. 26 (3): 403–14. doi:10.1016/j.molcel.2007.03.017. PMID 17499046.