SCYL2

SCY1-like protein 2 is a protein that in humans is encoded by the SCYL2 gene.[5][6]

SCYL2
Identifiers
Aliases	SCYL2, CVAK104, SCY1 like pseudokinase 2, AMCNACC
External IDs	OMIM: 616365 MGI: 1289172 HomoloGene: 13349 GeneCards: SCYL2
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q23.1 Start 100,267,140 bp[1] End 100,341,715 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C2|10 45.05 cM Start 89,638,721 bp[2] End 89,686,285 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • ATP binding • receptor binding • protein kinase activity • GO:0001948 protein binding Cellular component • Golgi apparatus • endosome membrane • membrane • cytoplasmic vesicle • clathrin-coated vesicle • cytoplasm • endosome • perinuclear region of cytoplasm Biological process • receptor internalization involved in canonical Wnt signaling pathway • negative regulation of canonical Wnt signaling pathway • protein phosphorylation • endosome to lysosome transport • positive regulation of clathrin-dependent endocytosis • positive regulation of receptor internalization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55681	213326
Ensembl	ENSG00000136021	ENSMUSG00000069539
UniProt	Q6P3W7	Q8CFE4
RefSeq (mRNA)	NM_017988 NM_001317784 NM_001330253 NM_001330254 NM_001330256	NM_198021 NM_001310704 NM_001358843
RefSeq (protein)	NP_001304713 NP_001317182 NP_001317183 NP_001317185 NP_060458	NP_001297633 NP_932138 NP_001345772
Location (UCSC)	Chr 12: 100.27 – 100.34 Mb	Chr 10: 89.64 – 89.69 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000136021 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000069539 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (Apr 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
6. "Entrez Gene: SCYL2 SCY1-like 2 (S. cerevisiae)".

Further reading

• Borner GH, Rana AA, Forster R, et al. (2007). "CVAK104 is a Novel Regulator of Clathrin-mediated SNARE Sorting". Traffic. 8 (7): 893–903. doi:10.1111/j.1600-0854.2007.00576.x. PMC 2239300. PMID 17587408.
• Düwel M, Ungewickell EJ (2007). "Clathrin-dependent Association of CVAK104 with Endosomes and the Trans-Golgi Network". Mol. Biol. Cell. 17 (10): 4513–25. doi:10.1091/mbc.E06-05-0390. PMC 1635376. PMID 16914521.
• Schmid EM, Ford MG, Burtey A, et al. (2007). "Role of the AP2 β-Appendage Hub in Recruiting Partners for Clathrin-Coated Vesicle Assembly". PLoS Biol. 4 (9): e262. doi:10.1371/journal.pbio.0040262. PMC 1540706. PMID 16903783.
• Conner SD, Schmid SL (2005). "CVAK104 is a novel poly-L-lysine-stimulated kinase that targets the beta2-subunit of AP2". J. Biol. Chem. 280 (22): 21539–44. doi:10.1074/jbc.M502462200. PMID 15809293.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.