SCPEP1

Retinoid-inducible serine carboxypeptidase is an enzyme that in humans is encoded by the SCPEP1 gene.[5][6][7]

SCPEP1
Identifiers
Aliases	SCPEP1, HSCP1, RISC, serine carboxypeptidase 1
External IDs	MGI: 1921867 HomoloGene: 41443 GeneCards: SCPEP1
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q22 Start 56,978,129 bp[1] End 57,006,768 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 C Start 88,924,020 bp[2] End 88,955,465 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • carboxypeptidase activity • peptidase activity • hydrolase activity • serine-type carboxypeptidase activity Cellular component • extracellular region • cytosol • extracellular exosome Biological process • proteolysis involved in cellular protein catabolic process • retinoic acid metabolic process • negative regulation of blood pressure • proteolysis • positive regulation of blood vessel diameter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	59342	74617
Ensembl	ENSG00000121064	ENSMUSG00000000278
UniProt	Q9HB40	Q920A5
RefSeq (mRNA)	NM_021626	NM_029023
RefSeq (protein)	NP_067639	NP_083299
Location (UCSC)	Chr 17: 56.98 – 57.01 Mb	Chr 11: 88.92 – 88.96 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000121064 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000000278 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chen J, Streb JW, Maltby KM, Kitchen CM, Miano JM (Sep 2001). "Cloning of a novel retinoid-inducible serine carboxypeptidase from vascular smooth muscle cells". J Biol Chem. 276 (36): 34175–81. doi:10.1074/jbc.M104162200. PMID 11447226.
6. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
7. "Entrez Gene: SCPEP1 serine carboxypeptidase 1".

Further reading

• Robb GB, Rana TM (2007). "RNA helicase A interacts with RISC in human cells and functions in RISC loading". Mol. Cell. 26 (4): 523–37. doi:10.1016/j.molcel.2007.04.016. PMID 17531811.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.