SCAMP2

Secretory carrier-associated membrane protein 2 is a protein that in humans is encoded by the SCAMP2 gene.[5][6]

SCAMP2
Identifiers
Aliases	SCAMP2, secretory carrier membrane protein 2
External IDs	OMIM: 606912 MGI: 1346518 HomoloGene: 4163 GeneCards: SCAMP2
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q24.1 Start 74,843,730 bp[1] End 74,873,365 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 B Start 57,560,943 bp[2] End 57,588,795 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • integral component of membrane • endosome • recycling endosome membrane • Golgi apparatus • trans-Golgi network membrane • extracellular exosome • transport vesicle • intracellular membrane-bounded organelle • membrane • Golgi membrane Biological process • protein transport • post-Golgi vesicle-mediated transport • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10066	24044
Ensembl	ENSG00000140497	ENSMUSG00000040188
UniProt	O15127	Q9ERN0
RefSeq (mRNA)	NM_005697 NM_001320778	NM_022813 NM_001378928
RefSeq (protein)	NP_001307707 NP_005688	NP_073724 NP_001365857
Location (UCSC)	Chr 15: 74.84 – 74.87 Mb	Chr 9: 57.56 – 57.59 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene product belongs to the SCAMP family of proteins which are secretory carrier membrane proteins. They function as carriers to the cell surface in post-golgi recycling pathways. Different family members are highly related products of distinct genes, and are usually expressed together. These findings suggest that the SCAMPs may function at the same site during vesicular transport rather than in separate pathways.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000140497 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040188 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Singleton DR, Wu TT, Castle JD (Nov 1997). "Three mammalian SCAMPs (secretory carrier membrane proteins) are highly related products of distinct genes having similar subcellular distributions". J Cell Sci. 110 (17): 2099–107. PMID 9378760.
6. "Entrez Gene: SCAMP2 secretory carrier membrane protein 2".

Further reading

• Wu TT, Castle JD (1997). "Evidence for colocalization and interaction between 37 and 39 kDa isoforms of secretory carrier membrane proteins (SCAMPs)". J. Cell Sci. 110 (13): 1533–41. PMID 9224770.
• Guo Z, Liu L, Cafiso D, Castle D (2002). "Perturbation of a very late step of regulated exocytosis by a secretory carrier membrane protein (SCAMP2)-derived peptide". J. Biol. Chem. 277 (38): 35357–63. doi:10.1074/jbc.M202259200. PMID 12124380.
• Liu L, Guo Z, Tieu Q, et al. (2003). "Role of Secretory Carrier Membrane Protein SCAMP2 in Granule Exocytosis". Mol. Biol. Cell. 13 (12): 4266–78. doi:10.1091/mbc.E02-03-0136. PMC 138632. PMID 12475951.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Lin PJ, Williams WP, Luu Y, et al. (2005). "Secretory carrier membrane proteins interact and regulate trafficking of the organellar (Na+,K+)/H+ exchanger NHE7". J. Cell Sci. 118 (Pt 9): 1885–97. doi:10.1242/jcs.02315. PMID 15840657.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Müller HK, Wiborg O, Haase J (2006). "Subcellular redistribution of the serotonin transporter by secretory carrier membrane protein 2". J. Biol. Chem. 281 (39): 28901–9. doi:10.1074/jbc.M602848200. PMID 16870614.
• Liao H, Ellena J, Liu L, et al. (2007). "Secretory carrier membrane protein SCAMP2 and phosphatidylinositol 4,5-bisphosphate interactions in the regulation of dense core vesicle exocytosis". Biochemistry. 46 (38): 10909–20. doi:10.1021/bi701121j. PMID 17713930.

External links

• SCAMP2 human gene location in the UCSC Genome Browser.
• SCAMP2 human gene details in the UCSC Genome Browser.