SARS2

Seryl-tRNA synthetase, mitochondrial is an enzyme that in humans is encoded by the SARS2 gene.[5][6]

For the virus, see Severe acute respiratory syndrome coronavirus 2.

SARS2
Identifiers
Aliases	SARS2, SARS, SARSM, SERS, SYS, SerRS, SerRSmt, mtSerRS, seryl-tRNA synthetase 2, mitochondrial
External IDs	OMIM: 612804 MGI: 1919234 HomoloGene: 6073 GeneCards: SARS2
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.2 Start 38,915,266 bp[1] End 38,930,896 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B1|7 16.91 cM Start 28,741,992 bp[2] End 28,753,871 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • aminoacyl-tRNA ligase activity • nucleotide binding • ligase activity • ATP binding • serine-tRNA ligase activity • RNA binding Cellular component • cytoplasm • mitochondrial matrix • mitochondrion Biological process • tRNA aminoacylation for protein translation • protein biosynthesis • seryl-tRNA aminoacylation • selenocysteinyl-tRNA(Sec) biosynthetic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54938	71984
Ensembl	ENSG00000104835 ENSG00000283104	ENSMUSG00000070699
UniProt	Q9NP81	Q9JJL8
RefSeq (mRNA)	NM_017827 NM_001145901	NM_023637
RefSeq (protein)	NP_001139373 NP_060297	NP_076126
Location (UCSC)	Chr 19: 38.92 – 38.93 Mb	Chr 7: 28.74 – 28.75 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. ENSG00000283104 GRCh38: Ensembl release 89: ENSG00000104835, ENSG00000283104 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000070699 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yokogawa T, Shimada N, Takeuchi N, Benkowski L, Suzuki T, Omori A, Ueda T, Nishikawa K, Spremulli LL, Watanabe K (Aug 2000). "Characterization and tRNA recognition of mammalian mitochondrial seryl-tRNA synthetase". J Biol Chem. 275 (26): 19913–20. doi:10.1074/jbc.M908473199. PMID 10764807.
6. "Entrez Gene: SARS2 seryl-tRNA synthetase 2, mitochondrial".

Further reading

• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Müller T, Deschauer M, Neudecker S, Zierz S (2007). "Late-onset mitochondrial myopathy with dystrophic changes due to a G7497A mutation in the mitochondrial tRNA(Ser(UCN)) gene". Acta Neuropathol. 110 (4): 426–30. doi:10.1007/s00401-005-1063-z. PMID 16133542.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ihalamulla RL, Liyanage CP, Karunaweera ND (2004). "A simple device to maintain in vitro cultures of Leishmania in tropical countries". Trans. R. Soc. Trop. Med. Hyg. 98 (5): 315–7. doi:10.1016/j.trstmh.2003.10.004. PMID 15109557.
• Gibbons WJ, Yan Q, Li R, et al. (2004). "Genomic organization, expression, and subcellular localization of mouse mitochondrial seryl-tRNA synthetase". Biochem. Biophys. Res. Commun. 317 (3): 774–8. doi:10.1016/j.bbrc.2004.03.113. PMID 15081407.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Casas C, Ribera J, Esquerda JE (2001). "Antibodies against c-Jun N-terminal peptide cross-react with neo-epitopes emerging after caspase-mediated proteolysis during apoptosis". J. Neurochem. 77 (3): 904–15. doi:10.1046/j.1471-4159.2001.00314.x. PMID 11331419.