SARDH

Sarcosine dehydrogenase, mitochondrial is an enzyme that in humans is encoded by the SARDH gene.[5][6]

SARDH
Identifiers
Aliases	SARDH, BPR-2, DMGDHL1, SAR, SARD, SDH, sarcosine dehydrogenase
External IDs	OMIM: 604455 MGI: 2183102 HomoloGene: 5149 GeneCards: SARDH
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.2 Start 133,663,560 bp[1] End 133,739,955 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A3 Start 27,188,393 bp[2] End 27,248,337 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • oxidoreductase activity • sarcosine dehydrogenase activity Cellular component • mitochondrion • mitochondrial matrix • cytoplasm Biological process • oxidation-reduction process • choline catabolic process • sarcosine catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1757	192166
Ensembl	ENSG00000123453	ENSMUSG00000009614
UniProt	Q9UL12	Q99LB7
RefSeq (mRNA)	NM_001134707 NM_007101	NM_138665
RefSeq (protein)	NP_001128179 NP_009032	NP_619606
Location (UCSC)	Chr 9: 133.66 – 133.74 Mb	Chr 2: 27.19 – 27.25 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000123453 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000009614 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Eschenbrenner M, Jorns MS (Nov 1999). "Cloning and mapping of the cDNA for human sarcosine dehydrogenase, a flavoenzyme defective in patients with sarcosinemia". Genomics. 59 (3): 300–8. doi:10.1006/geno.1999.5886. PMID 10444331.
6. "Entrez Gene: SARDH sarcosine dehydrogenase".

Further reading

• Porter DH, Cook RJ, Wagner C (1986). "Enzymatic properties of dimethylglycine dehydrogenase and sarcosine dehydrogenase from rat liver". Arch. Biochem. Biophys. 243 (2): 396–407. doi:10.1016/0003-9861(85)90516-8. PMID 2417560.
• London RE, Gabel SA, Funk A (1988). "Metabolism of excess methionine in the liver of intact rat: an in vivo 2H NMR study". Biochemistry. 26 (22): 7166–72. doi:10.1021/bi00396a044. PMID 2447942.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Bergeron F, Otto A, Blache P, et al. (1998). "Molecular cloning and tissue distribution of rat sarcosine dehydrogenase". Eur. J. Biochem. 257 (3): 556–61. doi:10.1046/j.1432-1327.1998.2570556.x. PMID 9839943.
• Gilbert JR, Kumar A, Newey S, et al. (2000). "Physical and cDNA mapping in the DBH region of human chromosome 9q34". Hum. Hered. 50 (3): 151–7. doi:10.1159/000022905. PMID 10686491.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.