SAMD4A
Sterile alpha motif domain containing 4A is a protein that in humans is encoded by the SAMD4A gene. [5]
Function
Sterile alpha motifs (SAMs) in proteins such as SAMD4A are part of an RNA-binding domain that functions as a posttranscriptional regulator by binding to an RNA sequence motif known as the Smaug recognition element, which was named after the Drosophila Smaug protein (Baez and Boccaccio, 2005 [PubMed 16221671]).[supplied by OMIM, Mar 2008].
gollark: no, contribute to potatOS.
gollark: My thing:- redefines FS functions in new env table- deep-copies a bunch of permitted APIs/libraries into it- redefines getfenv, load in env table- runs init file in new environment via `load`
gollark: And I think it's defaulting to the environment outside the sandbox, somehow.
gollark: os.run is run inside that init file.
gollark: Do I need to redefine os.run or something stupid for this?
References
- GRCh38: Ensembl release 89: ENSG00000020577 - Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000021838 - Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Entrez Gene: Sterile alpha motif domain containing 4A". Retrieved 2020-04-16.
Further reading
- Baez MV, Boccaccio GL (December 2005). "Mammalian Smaug is a translational repressor that forms cytoplasmic foci similar to stress granules". J. Biol. Chem. 280 (52): 43131–40. doi:10.1074/jbc.M508374200. PMID 16221671.
- Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD (November 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
- Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
- Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S (October 2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.
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