S100A14

S100 calcium binding protein A14 (S100A14) is a protein that in humans is encoded by the S100A14 gene.[5]

S100A14
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesS100A14, BCMP84, S100A15, S100 calcium binding protein A14
External IDsOMIM: 607986 MGI: 1913416 HomoloGene: 10781 GeneCards: S100A14
Gene location (Human)
Chr.Chromosome 1 (human)[1]
Band1q21.3Start153,614,255 bp[1]
End153,616,986 bp[1]
Orthologs
SpeciesHumanMouse
Entrez

57402

66166

Ensembl

ENSG00000189334

ENSMUSG00000042306

UniProt

Q9HCY8

Q9D2Q8

RefSeq (mRNA)

NM_020672

NM_001163525
NM_001163526
NM_025393

RefSeq (protein)

NP_065723

NP_001156997
NP_001156998
NP_079669

Location (UCSC)Chr 1: 153.61 – 153.62 MbChr 3: 90.53 – 90.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function.[6][7]

References

  1. GRCh38: Ensembl release 89: ENSG00000189334 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000042306 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: S100 calcium binding protein A14".
  6. Wang HY, Zhang JY, Cui JT, Tan XH, Li WM, Gu J, Lu YY (Jan 2010). "Expression status of S100A14 and S100A4 correlates with metastatic potential and clinical outcome in colorectal cancer after surgery". Oncology Reports. 23 (1): 45–52. doi:10.3892/or_00000604. PMID 19956863.
  7. Chen H, Yu D, Luo A, Tan W, Zhang C, Zhao D, Yang M, Liu J, Lin D, Liu Z (Apr 2009). "Functional role of S100A14 genetic variants and their association with esophageal squamous cell carcinoma". Cancer Research. 69 (8): 3451–7. doi:10.1158/0008-5472.CAN-08-4231. PMID 19351828.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.