S100A13

S100 calcium-binding protein A13 (S100A13) is a protein that in humans is encoded by the S100A13 gene.[5][6]

S100A13
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1YUR, 1YUS, 1YUT, 1YUU, 2EGD, 2H2K, 2K8M, 2KI4, 2KI6, 2KOT, 2L5X, 2LE9
Identifiers
Aliases	S100A13, S100 calcium binding protein A13
External IDs	OMIM: 601989 MGI: 109581 HomoloGene: 7523 GeneCards: S100A13
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 153,618,787 bp[1] End 153,631,360 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 F1|3 39.24 cM Start 90,514,435 bp[2] End 90,524,581 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • calcium ion binding • protein homodimerization activity • zinc ion binding • metal ion binding • GO:0001948 protein binding • RAGE receptor binding • fibroblast growth factor binding • copper ion binding • lipid binding Cellular component • cytoplasm • cytosol • perinuclear region of cytoplasm • cell nucleus • mast cell granule • extracellular • nucleolus • cell membrane • extracellular region Biological process • interleukin-1 alpha secretion • response to copper ion • cytokine secretion • response to electrical stimulus • positive regulation of cell proliferation • regulation of cell shape • protein transport • positive regulation of I-kappaB kinase/NF-kappaB signaling • mast cell degranulation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6284	20196
Ensembl	ENSG00000189171	ENSMUSG00000042312
UniProt	Q99584	P97352
RefSeq (mRNA)	NM_001024210 NM_001024211 NM_001024212 NM_001024213 NM_005979	NM_009113
RefSeq (protein)	NP_001019381 NP_001019382 NP_001019383 NP_001019384 NP_005970	NP_033139
Location (UCSC)	Chr 1: 153.62 – 153.63 Mb	Chr 3: 90.51 – 90.52 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is widely expressed in various types of tissues with a high expression level in thyroid gland. In smooth muscle cells, this protein co-expresses with other family members in the nucleus and in stress fibers, suggesting diverse functions in signal transduction. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.[6]

Interactions

S100A13 has been shown to interact with SYT1[7][8] and FGF1.[7][8]

Pathology

Up-regulation of S100A13 was detected in cystic papillary thyroid carcinoma[9] and association of S100A13 expression and chemotherapy resistance was shown in proteomics study of melanoma.[10]

References

1. GRCh38: Ensembl release 89: ENSG00000189171 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042312 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wicki R, Marenholz I, Mischke D, Schäfer BW, Heizmann CW (Dec 1996). "Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21". Cell Calcium. 20 (6): 459–64. doi:10.1016/S0143-4160(96)90087-1. PMID 8985590.
6. "Entrez Gene: S100A13 S100 calcium binding protein A13".
7. Mouta Carreira C, LaVallee TM, Tarantini F, Jackson A, Lathrop JT, Hampton B, Burgess WH, Maciag T (Aug 1998). "S100A13 is involved in the regulation of fibroblast growth factor-1 and p40 synaptotagmin-1 release in vitro". The Journal of Biological Chemistry. 273 (35): 22224–31. doi:10.1074/jbc.273.35.22224. PMID 9712836.
8. Landriscina M, Bagalá C, Mandinova A, Soldi R, Micucci I, Bellum S, Prudovsky I, Maciag T (Jul 2001). "Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress". The Journal of Biological Chemistry. 276 (27): 25549–57. doi:10.1074/jbc.M102925200. PMID 11432880.
9. Dinets A, Pernemalm M, Kjellin H, Sviatoha V, Sofiadis A, Juhlin CC, Zedenius J, Larsson C, Lehtiö J, Höög A (May 2015). "Differential protein expression profiles of cyst fluid from papillary thyroid carcinoma and benign thyroid lesions". PLOS ONE. 10 (5): e0126472. doi:10.1371/journal.pone.0126472. PMC 4433121. PMID 25978681.
10. Azimi A, Pernemalm M, Frostvik Stolt M, Hansson J, Lehtiö J, Egyházi Brage S, Hertzman Johansson C. "Proteomics analysis of melanoma metastases: association between S100A13 expression and chemotherapy resistance". British Journal of Cancer. 110: 2489–2495. doi:10.1038/bjc.2014.169. PMC 4021518. PMID 24722184.

Further reading

• Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (Sep 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
• Schäfer BW, Wicki R, Engelkamp D, Mattei MG, Heizmann CW (Feb 1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics. 25 (3): 638–43. doi:10.1016/0888-7543(95)80005-7. PMID 7759097.
• Wicki R, Schäfer BW, Erne P, Heizmann CW (Oct 1996). "Characterization of the human and mouse cDNAs coding for S100A13, a new member of the S100 protein family". Biochemical and Biophysical Research Communications. 227 (2): 594–9. doi:10.1006/bbrc.1996.1551. PMID 8878558.
• Mouta Carreira C, LaVallee TM, Tarantini F, Jackson A, Lathrop JT, Hampton B, Burgess WH, Maciag T (Aug 1998). "S100A13 is involved in the regulation of fibroblast growth factor-1 and p40 synaptotagmin-1 release in vitro". The Journal of Biological Chemistry. 273 (35): 22224–31. doi:10.1074/jbc.273.35.22224. PMID 9712836.
• Ridinger K, Schäfer BW, Durussel I, Cox JA, Heizmann CW (Mar 2000). "S100A13. Biochemical characterization and subcellular localization in different cell lines". The Journal of Biological Chemistry. 275 (12): 8686–94. doi:10.1074/jbc.275.12.8686. PMID 10722710.
• Landriscina M, Bagalá C, Mandinova A, Soldi R, Micucci I, Bellum S, Prudovsky I, Maciag T (Jul 2001). "Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress". The Journal of Biological Chemistry. 276 (27): 25549–57. doi:10.1074/jbc.M102925200. PMID 11432880.
• Hsieh HL, Schäfer BW, Cox JA, Heizmann CW (Aug 2002). "S100A13 and S100A6 exhibit distinct translocation pathways in endothelial cells". Journal of Cell Science. 115 (Pt 15): 3149–58. PMID 12118070.
• Prudovsky I, Bagala C, Tarantini F, Mandinova A, Soldi R, Bellum S, Maciag T (Jul 2002). "The intracellular translocation of the components of the fibroblast growth factor 1 release complex precedes their assembly prior to export". The Journal of Cell Biology. 158 (2): 201–8. doi:10.1083/jcb.200203084. PMC 2173119. PMID 12135982.
• Chan WY, Xia CL, Dong DC, Heizmann CW, Yew DT (Apr 2003). "Differential expression of S100 proteins in the developing human hippocampus and temporal cortex". Microscopy Research and Technique. 60 (6): 600–13. doi:10.1002/jemt.10302. PMID 12645008.
• Mandinova A, Soldi R, Graziani I, Bagala C, Bellum S, Landriscina M, Tarantini F, Prudovsky I, Maciag T (Jul 2003). "S100A13 mediates the copper-dependent stress-induced release of IL-1alpha from both human U937 and murine NIH 3T3 cells" (PDF). Journal of Cell Science. 116 (Pt 13): 2687–96. doi:10.1242/jcs.00471. PMID 12746488.
• Hsieh HL, Schäfer BW, Weigle B, Heizmann CW (Apr 2004). "S100 protein translocation in response to extracellular S100 is mediated by receptor for advanced glycation endproducts in human endothelial cells". Biochemical and Biophysical Research Communications. 316 (3): 949–59. doi:10.1016/j.bbrc.2004.02.135. PMID 15033494.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (Jan 2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Hayrabedyan S, Kyurkchiev S, Kehayov I (Mar 2005). "Endoglin (cd105) and S100A13 as markers of active angiogenesis in endometriosis". Reproductive Biology. 5 (1): 51–67. PMID 15821778.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Oh JH, Yang JO, Hahn Y, Kim MR, Byun SS, Jeon YJ, Kim JM, Song KS, Noh SM, Kim S, Yoo HS, Kim YS, Kim NS (Dec 2005). "Transcriptome analysis of human gastric cancer". Mammalian Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674.