Ribosomal protein leader

A ribosomal protein leader is a mechanism used in cells to control the cellular concentration of a protein that forms a part of the ribosome, and to make sure that the concentration is neither too high nor too low.[1] Ribosomal protein leaders are RNA sequences that are a part of the 5' UTR of mRNAs encoding a ribosomal protein. When cellular concentrations of the ribosomal protein are high, excess protein will bind to the mRNA leader. This binding event can lower gene expression via a number of mechanisms; for example, in the protein-bound state, the RNA could form an intrinsic transcription termination stem-loop. When cellular concentrations of the ribosomal protein are not high, they are occupied in the ribosome, and are not available in significant quantities to bind the mRNA leader. This leads to increased expression of the gene, which leads to the synthesis of more copies of the ribosomal protein. Many examples of ribosomal protein leaders are known in bacteria, including ribosomal protein L20 leader[1] and ribosomal S15 leader.[2]

See also
Ribosome subunits
Small subunit Large subunit
L2 Ribosomal protein leader
L4 Ribosomal protein leader
S10 Ribosomal protein leaderL10 Ribosomal protein leader
S15 Ribosomal protein leader L13 Ribosomal protein leader
S4 Ribosomal protein leader L19 Ribosomal protein leader
S16 Ribosomal protein leader L20 Ribosomal protein leader
S6:S18 Ribosomal protein leader L21 Ribosomal protein leader
L25 Ribosomal protein leader
eL15 Ribosomal protein leader
L17 Ribosomal protein leader
L31 Ribosomal protein leader

References
  1. Zengel JM, Lindahl L (1994). "Diverse mechanisms for regulating ribosomal protein synthesis in Escherichia coli". Prog. Nucleic Acid Res. Mol. Biol. Progress in Nucleic Acid Research and Molecular Biology. 47: 331–370. doi:10.1016/S0079-6603(08)60256-1. ISBN 978-0-12-540047-3. PMID 7517053.
  2. Benard, L; Philippe C; Ehresmann B; Ehresmann C; Portier C (1996). "Pseudoknot and translational control in the expression of the S15 ribosomal protein". Biochimie. 78 (7): 568–576. doi:10.1016/S0300-9084(96)80003-4. PMC 7131963. PMID 8955900.
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