Retinyl acetate
Retinyl acetate (retinol acetate, vitamin A acetate) is a natural form of vitamin A which is the acetate ester of retinol. It has potential antineoplastic and chemopreventive activities.[2][3]
Names | |
---|---|
IUPAC name
(2E,4E,6E,8E)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-yl acetate | |
Other names
Retinol acetate; Vitamin A acetate; Vitamin A1 acetate; Acetylretinol; all-trans-Retinol acetate; all-trans-Retinyl acetate; all-trans-Vitamin A acetate; | |
Identifiers | |
3D model (JSmol) |
|
ChemSpider | |
ECHA InfoCard | 100.004.405 |
PubChem CID |
|
UNII | |
CompTox Dashboard (EPA) |
|
| |
| |
Properties | |
C22H32O2 | |
Molar mass | 328.496 g·mol−1 |
Melting point | 57 to 58 °C (135 to 136 °F; 330 to 331 K)[1] |
Hazards | |
R-phrases (outdated) | R38-R63[1] |
S-phrases (outdated) | S36/37[1] |
NFPA 704 (fire diamond) | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
Infobox references | |
In the United States, retinyl acetate is classified generally recognized as safe (GRAS) in the amounts used to fortify foods with vitamin A.[4][5]
Teratogenicity
World Health Organization recommendation on Maternal Supplementation During Pregnancy states that "health benefits are expected for the mother and her developing fetus with little risk of detriment to either, from a daily supplement not exceeding 10,000 IU vitamin A (3000mcg RE) at any time during pregnancy." Preformed Vitamin A refers to retinyl palmitate and retinyl acetate. [6]
gollark: I find digital systems waaay better for preserving things than physical media, unless there's some DRM stuff in play.
gollark: Very fancy clothes might come with fabricators in them to make small things you want from the pockets but which they don't actually contain.
gollark: The Kindle reader applications have a nice feature where you can select a word and it pulls the definition from the dictionary.
gollark: What is this ”project” of which you speak?
gollark: I just block all ads everywhere unless they follow some standards (no persistent tracking, static images only, clearly delineated ads, small out of the way ones), since it's basically the only thing I can do to influence advertisers.
References
- Retinyl acetate from Sigma-Aldrich
- Moon, Richard C.; Grubbs, Clinton J.; Sporn, Michael B.; Goodman, Dawn G. (1977). "Retinyl acetate inhibits mammary carcinogenesis induced by N-methyl-N-nitrosourea". Nature. 267 (5612): 620–1. doi:10.1038/267620a0. PMID 876383.
- Retinyl acetate, National Cancer Institute Drug Dictionary
- Select Committee on GRAS Substances (SCOGS) Opinion: Vitamin A, United States Food and Drug Administration
- 21 C.F.R. 184.1930
- http://whqlibdoc.who.int/hq/1998/WHO_NUT_98.4_eng.pdf
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.