Reductive stress

Reductive stress is the counterpart to oxidative stress, where electron acceptors are expected to be mostly reduced. It can be caused by excess amounts of glutathione, and can contribute to cytotoxicity.[1][2]

See also

References
  1. Zhang, H; Limphong, P; Pieper, J; Liu, Q; Rodesch, CK; Christians, E; Benjamin, IJ (2012). "Glutathione-dependent reductive stress triggers mitochondrial oxidation and cytotoxicity". FASEB J. 26 (4): 1442–51. doi:10.1096/fj.11-199869. PMC 3316899. PMID 22202674.
  2. Korge, Paavo; Calmettes, Guillaume; Weiss, James N. (2015). "Increased reactive oxygen species production during reductive stress: The roles of mitochondrial glutathione and thioredoxin reductases". Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1847 (6–7): 514–525. doi:10.1016/j.bbabio.2015.02.012. PMC 4426053. PMID 25701705.
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