Ravgen

Ravgen Inc., is a privately owned biotech company founded by Chairman and C.E.O. Dr. Ravinder Dhallan. Ravgen Inc. is known for its research in the prenatal diagnostic field and its development of non-invasive prenatal diagnosis testing which was published in The Lancet (Lancet. 2007; 369:474-81),[2] the Journal of the American Medical Association (JAMA. 2004;291:1114-1119).,[3] and the New England Journal of Medicine (NEJM. 2012; 366:1743-1745).[4] These publications received worldwide press in The Times, The Washington Post (February 2007),[5] CNN Fortune Small Business (September 2007),[6] and The New York Times (June 2012) [7]

[1]

Ravgen was founded in 2000 in Columbia, Maryland by Dr. Ravinder Dhallan. Dr. Dhallan received doctorates in medicine and biomedical engineering at The Johns Hopkins University as well as an MBA from the Wharton School of Business at the University of Pennsylvania. The CEO and founder of the company held residency positions in oncology at Massachusetts General Hospital and in emergency medicine at York Hospital in York, PA before becoming an attending physician in the Department of Emergency Medicine at Holy Cross Hospital in Silver Spring, MD.

Dr. Dhallan left his position at Holy Cross in 2000 in order to start his own company, Ravgen, with the pursuit of developing a safer prenatal diagnostic exam. At the time the only options available to patients were invasive with a chance of miscarriage or lacked in accuracy. Since its start in 2000, Ravgen has developed and patented a variety of safe, accurate prenatal diagnostic tests that simply require a blood draw from the mother. The company's core technology is based on its ability to increase the percentage of fetal DNA that is found in the maternal bloodstream, something that scientists have attempted to do for decades with little success. With this breakthrough in medicine, Ravgen is able to offer safe, noninvasive, pre-birth testing alternatives for expectant mothers and give them the knowledge they need to prepare for their pregnancies.

Timeline
  • fall 2000: Ravgen founded.
  • March 2004: Ravgen publishes first clinical study in the Journal of the American Medical Association [8]
  • February 2007: Ravgen publishes second clinical study in the Lancet [9]
  • fall 2007: Ravgen Diagnostics founded
  • May 2012: Ravgen publishes third clinical study in the New England Journal of Medicine [10]

Competition

Companies and universities that are working towards developing non-invasive prenatal testing include Natera, Sequenom, Artemis Health,[11] Lenetix,[12] Ikonisys, Fluidigm,[13] and Stanford University.[14]

Media coverage

Ravgen has published its genetic research in internationally recognized, peer reviewed articles including JAMA (the Journal of the American Medical Association) in 2004, The Lancet in 2007, and the New England Journal of Medicine in 2012. In addition, Ravgen has received local[15] and global[16] media coverage on its non-invasive prenatal DNA testing. Articles about the company and its research have been published in CNN Fortune Small Business,[17] The Times, The Washington Post, Technology Review MIT,[18] BBC News, Reuters, Health Day,[19] WUSA, and The New York Times (June 2012).[7]

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References
  1. Hanoon, Alaa; Rahan, Nur Nadiah Mohd; Hamid, Nur Nadiah Abd; Ismail, Ahmad Izani Md (2018). "Solving the nonlinear Camassa Holm equation using quartic trigonometric B-spline collocation method". AIP Conference Proceedings. 1974. Author(s): 020034. doi:10.1063/1.5041565. Cite journal requires |journal= (help)
  2. Dhallan, Ravinder (2007). "A non-invasive test for prenatal diagnosis based on fetal DNA present in maternal blood: a preliminary study". The Lancet. 369 (9560): 474–481. doi:10.1016/S0140-6736(07)60115-9. PMID 17292767.
  3. "JAMA Network | JAMA | Methods to Increase the Percentage of Free Fetal DNA Recovered From the Maternal Circulation". Jama.ama-assn.org. Archived from the original on January 13, 2010. Retrieved August 17, 2013.
  4. MMS: Error Archived December 28, 2013, at the Wayback Machine
  5. "Experimental Prenatal Test Helps Spot Birth Defects". Washingtonpost.com. February 2, 2007. Retrieved August 17, 2013.
  6. "Fortune Small Business "A Shot in the Arm Keeps Fetuses Safe" September 17, 2007". Fortune Small Business. Archived from the original on December 27, 2013.
  7. "The New York Times "Before Birth, Dad's I.D." June 20, 2012". The New York Times.
  8. "Methods to Increase the Percentage of Free Fetal DNA Recovered from the Maternal Circulation". The Journal of the American Medical Association. Archived from the original on May 11, 2012.
  9. Dhallan, Ravinder; Guo, Xin; Emche, Sarah; Damewood, Marian; Bayliss, Philip; Cronin, Michael; Barry, Julie; Betz, Jordan; Franz, Kara; Gold, Katie; Vallecillo, Brett; Varney, John (2007). "A noninvasive test for prenatal diagnosis based on fetal DNA present in maternal blood: a preliminary study". The Lancet. 369 (9560): 474–481. doi:10.1016/S0140-6736(07)60115-9. PMID 17292767.
  10. Guo, Xin (2012). "A Noninasive Test to Determine Paternity in Pregnancy". The New England Journal of Medicine. 366 (18): 1743–1745. doi:10.1056/NEJMc1113044. PMID 22551147.
  11. "Verinata". Artemishealthinc.com. July 31, 2013. Archived from the original on March 7, 2011. Retrieved August 17, 2013.
  12. "Lenetix Launches Screening Study Of New Down Syndrome Test". Medicalnewstoday.com. Archived from the original on March 17, 2010. Retrieved August 17, 2013.
  13. Businessweek - Business News, Stock market & Financial Advice Archived September 12, 2011, at the Wayback Machine
  14. "Non-invasive prenatal test for Down's syndrome developed". BioNews. Archived from the original on December 27, 2013. Retrieved August 17, 2013.
  16. "Health | Hope for safe prenatal gene test". BBC News. February 2, 2007. Archived from the original on April 19, 2012. Retrieved August 17, 2013.
  17. "A shot in the arm keeps fetuses safe - Sep. 12, 2007". Money.cnn.com. September 12, 2007. Archived from the original on December 6, 2013. Retrieved August 17, 2013.
  18. Humphries, Courtney (February 2, 2007). "A Simpler Test for Detecting Down's Syndrome | MIT Technology Review". Technologyreview.com. Retrieved August 17, 2013.
  19. "Who's the Dad? First-Trimester Blood Test May Tell". Consumer.healthday.com. Retrieved August 17, 2013.
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