RWDD3

RWD domain-containing protein 3 is a protein that in humans is encoded by the RWDD3 gene.[5][6]

RWDD3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EBK, 4Y1L
Identifiers
Aliases	RWDD3, RSUME, RWD domain containing 3
External IDs	OMIM: 615875 MGI: 1920420 HomoloGene: 22899 GeneCards: RWDD3
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p21.3 Start 95,234,210 bp[1] End 95,247,225 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 G1 Start 121,155,398 bp[2] End 121,171,695 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cytoplasm • cell nucleus Biological process • negative regulation of NF-kappaB transcription factor activity • positive regulation of protein sumoylation • positive regulation of hypoxia-inducible factor-1alpha signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	25950	66568
Ensembl	ENSG00000122481	ENSMUSG00000028133
UniProt	Q9Y3V2	Q8VIL2
RefSeq (mRNA)	NM_001128142 NM_001199682 NM_001278247 NM_001278248 NM_015485	NM_025637 NM_028456
RefSeq (protein)	NP_001121614 NP_001186611 NP_001265176 NP_001265177 NP_056300	n/a
Location (UCSC)	Chr 1: 95.23 – 95.25 Mb	Chr 3: 121.16 – 121.17 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000122481 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028133 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
6. "Entrez Gene: RWDD3 RWD domain containing 3".

Further reading

• Carbia-Nagashima A, Gerez J, Perez-Castro C, et al. (2008). "RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia". Cell. 131 (2): 309–23. doi:10.1016/j.cell.2007.07.044. PMID 17956732.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.