RUVBL2

RUVBL2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CQA, 2XSZ, 3UK6
Identifiers
Aliases	RUVBL2, ECP51, INO80J, REPTIN, RVB2, TIH2, TIP48, TIP49B, CGI-46, ECP-51, TAP54-beta, RuvB like AAA ATPase 2
External IDs	OMIM: 604788 MGI: 1342299 HomoloGene: 4856 GeneCards: RUVBL2
Gene location (Human)
Chr.	Chromosome 19 (human)[1]
End	49,015,970 bp[1]
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)[2]
End	45,438,096 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • nucleotide binding; • GO:0043141 5'-3' DNA helicase activity; • GO:0008026 helicase activity; • unfolded protein binding; • GO:0004003 DNA helicase activity; • ATPase activity; • GO:0001948 protein binding; • identical protein binding; • chromatin DNA binding; • ATP binding; • hydrolase activity; • RNA polymerase II core promoter sequence-specific DNA binding; • TFIID-class transcription factor binding; • protein homodimerization activity; • ADP binding; • ATPase binding;
Cellular component	• nuclear euchromatin; • membrane; • nuclear matrix; • NuA4 histone acetyltransferase complex; • intracellular; • nucleoplasm; • MLL1 complex; • extracellular exosome; • cell nucleus; • Swr1 complex; • R2TP complex; • cytoplasm; • centrosome; • cytosol; • Ino80 complex;
Biological process	• chromatin remodeling; • DNA recombination; • regulation of transcription, DNA-templated; • transcriptional activation by promoter-enhancer looping; • cellular response to UV; • histone H2A acetylation; • cellular response to estradiol stimulus; • transcription, DNA-templated; • positive regulation of histone acetylation; • cellular response to DNA damage stimulus; • establishment of protein localization to chromatin; • protein folding; • positive regulation of telomerase RNA localization to Cajal body; • histone H4 acetylation; • regulation of growth; • negative regulation of estrogen receptor binding; • DNA repair; • positive regulation of transcription from RNA polymerase II promoter; • DNA duplex unwinding; • covalent chromatin modification; • box C/D snoRNP assembly;
	Sources:Amigo / QuickGO
Orthologs
	10856
	20174
	ENSG00000183207
	ENSMUSG00000003868
	Q9Y230
	Q9WTM5
	NM_006666; NM_001321190; NM_001321191
	NM_011304
	NP_001308119; NP_001308120; NP_006657
	NP_035434
	Wikidata
View/Edit Human	View/Edit Mouse

RuvB-like 2 (E. coli), also known as RUVBL2, is a human gene coding for a protein belonging to the AAA+ family of proteins.

Function

This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. However, the evidence for whether RUVBL2 has DNA helicase activity is contradictory.[5] This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation.[6]

Interactions

RUVBL2 has been shown to interact with RuvB-like 1[7] and Activating transcription factor 2.[8]

gollark: I only have something like 60GB of vaguely important data, and 5GB I couldn't replace easily.

gollark: Currently looking at sending over a cheap RPi and external hard drive to a technical friend so I can replicate stuff offsite to them.

gollark: I don't have anywhere near enough backing up of stuff yet, unfortunately, really ought to work on that.

gollark: I probably get away with doing a lot of stuff weirdly because I have a lot of free time and very little actual demand on my server stuff, since the only user is me. Though I do have a lot of important data and random services.

gollark: I just use entirely open-source software on my servers (except gameservers and probably some drivers), and don't have to deal with that sort of problem.

References

GRCh38: Ensembl release 89: ENSG00000183207 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000003868 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Puri T, Wendler P, Sigala B, Saibil H, Tsaneva IR (Feb 2007). "Dodecameric structure and ATPase activity of the human TIP48/TIP49 complex". Journal of Molecular Biology. 366 (1): 179–92. doi:10.1016/j.jmb.2006.11.030. PMID 17157868.
"Entrez Gene: RUVBL2 RuvB-like 2 (E. coli)".
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Cho SG, Bhoumik A, Broday L, Ivanov V, Rosenstein B, Ronai Z (Dec 2001). "TIP49b, a regulator of activating transcription factor 2 response to stress and DNA damage". Molecular and Cellular Biology. 21 (24): 8398–413. doi:10.1128/MCB.21.24.8398-8413.2001. PMC 100004. PMID 11713276.

Doyon Y, Côté J (Apr 2004). "The highly conserved and multifunctional NuA4 HAT complex". Current Opinion in Genetics & Development. 14 (2): 147–54. doi:10.1016/j.gde.2004.02.009. PMID 15196461.
Kanemaki M, Kurokawa Y, Matsu-ura T, Makino Y, Masani A, Okazaki K, Morishita T, Tamura TA (Aug 1999). "TIP49b, a new RuvB-like DNA helicase, is included in a complex together with another RuvB-like DNA helicase, TIP49a". The Journal of Biological Chemistry. 274 (32): 22437–44. doi:10.1074/jbc.274.32.22437. PMID 10428817.
Salzer U, Kubicek M, Prohaska R (Sep 1999). "Isolation, molecular characterization, and tissue-specific expression of ECP-51 and ECP-54 (TIP49), two homologous, interacting erythroid cytosolic proteins". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1446 (3): 365–70. doi:10.1016/S0167-4781(99)00104-9. PMID 10524211.
Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (May 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Research. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
Wood MA, McMahon SB, Cole MD (Feb 2000). "An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc". Molecular Cell. 5 (2): 321–30. doi:10.1016/S1097-2765(00)80427-X. PMID 10882073.
Ikura T, Ogryzko VV, Grigoriev M, Groisman R, Wang J, Horikoshi M, Scully R, Qin J, Nakatani Y (Aug 2000). "Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis". Cell. 102 (4): 463–73. doi:10.1016/S0092-8674(00)00051-9. PMID 10966108.
Parfait B, Giovangrandi Y, Asheuer M, Laurendeau I, Olivi M, Vodovar N, Vidaud D, Vidaud M, Bièche I (2000). "Human TIP49b/RUVBL2 gene: genomic structure, expression pattern, physical link to the human CGB/LHB gene cluster on chromosome 19q13.3". Annales de Génétique. 43 (2): 69–74. doi:10.1016/S0003-3995(00)01016-9. PMID 10998447.
Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Bauer A, Chauvet S, Huber O, Usseglio F, Rothbächer U, Aragnol D, Kemler R, Pradel J (Nov 2000). "Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity". The EMBO Journal. 19 (22): 6121–30. doi:10.1093/emboj/19.22.6121. PMC 305835. PMID 11080158.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Cho SG, Bhoumik A, Broday L, Ivanov V, Rosenstein B, Ronai Z (Dec 2001). "TIP49b, a regulator of activating transcription factor 2 response to stress and DNA damage". Molecular and Cellular Biology. 21 (24): 8398–413. doi:10.1128/MCB.21.24.8398-8413.2001. PMC 100004. PMID 11713276.
Park J, Wood MA, Cole MD (Mar 2002). "BAF53 forms distinct nuclear complexes and functions as a critical c-Myc-interacting nuclear cofactor for oncogenic transformation". Molecular and Cellular Biology. 22 (5): 1307–16. doi:10.1128/MCB.22.5.1307-1316.2002. PMC 134713. PMID 11839798.
Ohta S, Shiomi Y, Sugimoto K, Obuse C, Tsurimoto T (Oct 2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein". The Journal of Biological Chemistry. 277 (43): 40362–7. doi:10.1074/jbc.M206194200. PMID 12171929.
Watkins NJ, Dickmanns A, Lührmann R (Dec 2002). "Conserved stem II of the box C/D motif is essential for nucleolar localization and is required, along with the 15.5K protein, for the hierarchical assembly of the box C/D snoRNP" (PDF). Molecular and Cellular Biology. 22 (23): 8342–52. doi:10.1128/MCB.22.23.8342-8352.2002. PMC 134055. PMID 12417735.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Cai Y, Jin J, Tomomori-Sato C, Sato S, Sorokina I, Parmely TJ, Conaway RC, Conaway JW (Oct 2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". The Journal of Biological Chemistry. 278 (44): 42733–6. doi:10.1074/jbc.C300389200. PMID 12963728.
Gstaiger M, Luke B, Hess D, Oakeley EJ, Wirbelauer C, Blondel M, Vigneron M, Peter M, Krek W (Nov 2003). "Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI". Science. 302 (5648): 1208–12. doi:10.1126/science.1088401. PMID 14615539.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183207 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003868 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Puri T, Wendler P, Sigala B, Saibil H, Tsaneva IR (Feb 2007). "Dodecameric structure and ATPase activity of the human TIP48/TIP49 complex". Journal of Molecular Biology. 366 (1): 179–92. doi:10.1016/j.jmb.2006.11.030. PMID 17157868.

[entrez-6] "Entrez Gene: RUVBL2 RuvB-like 2 (E. coli)".

[pmid17353931-7] Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

[pmid11713276-8] Cho SG, Bhoumik A, Broday L, Ivanov V, Rosenstein B, Ronai Z (Dec 2001). "TIP49b, a regulator of activating transcription factor 2 response to stress and DNA damage". Molecular and Cellular Biology. 21 (24): 8398–413. doi:10.1128/MCB.21.24.8398-8413.2001. PMC 100004. PMID 11713276.

RUVBL2

Function

Interactions

References

Further reading