RUN domain
The RUN domain is an evolutionary conserved protein–protein binding protein domain. They often interact with GTPases and could play a role in multiple Ras-like GTPase signalling pathways.
| RUN domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | RUN | ||||||||
| Pfam | PF02759 | ||||||||
| InterPro | IPR004012 | ||||||||
| |||||||||
This domain is present in several proteins that are linked to the functions of GTPases in the Rap and Rab families. They could hence play important roles in multiple Ras-like GTPase signaling pathways. The domain comprises six conserved regions, which in some proteins have considerable insertions between them. The domain core is thought to take up a predominantly alpha fold, with basic amino acids in regions A and D possibly playing a functional role in interactions with Ras GTPases.[1]
Examples
Human genes encoding proteins containing this domain include:
- LOC440456;
- PLEKHM1; PLEKHM2;
- RAB6IP1; RPIB9; RPIP8; RUFY1; RUFY2; RUFY3; RUFY4; RUNDC1; RUNDC2A; RUNDC3B; RUSC1; RUSC2;
- SGSM1; SGSM2; SGSM3;
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References
- Callebaut I, de Gunzburg J, Goud B, Mornon JP (February 2001). "RUN domains: a new family of domains involved in Ras-like GTPase signaling". Trends Biochem. Sci. 26 (2): 79–83. doi:10.1016/s0968-0004(00)01730-8. PMID 11166556.
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