RTN2

Reticulon-2 is a protein that in humans is encoded by the RTN2 gene.[5][6][7]

RTN2
Identifiers
Aliases	RTN2, NSP2, NSPL1, NSPLI, SPG12, reticulon 2
External IDs	OMIM: 603183 MGI: 107612 HomoloGene: 32180 GeneCards: RTN2
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.32 Start 45,485,294 bp[1] End 45,497,055 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A3|7 9.54 cM Start 19,282,624 bp[2] End 19,296,160 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • integral component of membrane • T-tubule • integral component of endoplasmic reticulum membrane • endoplasmic reticulum membrane • endoplasmic reticulum • membrane • terminal cisterna Biological process • intracellular protein transmembrane transport • regulation of glucose import Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6253	20167
Ensembl	ENSG00000125744	ENSMUSG00000030401
UniProt	O75298 Q96CG9	O70622
RefSeq (mRNA)	NM_206902 NM_005619 NM_206900 NM_206901	NM_001025364 NM_013648
RefSeq (protein)	NP_005610 NP_996783 NP_996784	NP_001020535 NP_038676
Location (UCSC)	Chr 19: 45.49 – 45.5 Mb	Chr 7: 19.28 – 19.3 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Alternatively spliced transcript variants encoding different isoforms have been identified.[7]

References

1. GRCh38: Ensembl release 89: ENSG00000125744 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030401 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Stubbs L, Carver EA, Shannon ME, Kim J, Geisler J, Generoso EE, Stanford BG, Dunn WC, Mohrenweiser H, Zimmermann W, Watt SM, Ashworth LK (Dec 1996). "Detailed comparative map of human chromosome 19q and related regions of the mouse genome" (PDF). Genomics. 35 (3): 499–508. doi:10.1006/geno.1996.0390. PMID 8812484.
6. Geisler JG, Stubbs LJ, Wasserman WW, Mucenski ML (May 1998). "Molecular cloning of a novel mouse gene with predominant muscle and neural expression". Mamm Genome. 9 (4): 274–82. doi:10.1007/s003359900748. PMID 9530622.
7. "Entrez Gene: RTN2 reticulon 2".

Further reading

• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• He W, Lu Y, Qahwash I, et al. (2004). "Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation". Nat. Med. 10 (9): 959–65. doi:10.1038/nm1088. PMID 15286784.
• Reuter TY, Medhurst AL, Waisfisz Q, et al. (2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport". Exp. Cell Res. 289 (2): 211–21. doi:10.1016/S0014-4827(03)00261-1. PMID 14499622.
• Oertle T, Klinger M, Stuermer CA, Schwab ME (2003). "A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family". FASEB J. 17 (10): 1238–47. doi:10.1096/fj.02-1166hyp. PMID 12832288.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Geisler JG, Palmer RJ, Stubbs LJ, Mucenski ML (2000). "Nspl1, a new Z-band-associated protein". J. Muscle Res. Cell. Motil. 20 (7): 661–8. doi:10.1023/A:1005533013926. PMID 10672514.
• Roebroek AJ, Contreras B, Pauli IG, Van de Ven WJ (1998). "cDNA cloning, genomic organization, and expression of the human RTN2 gene, a member of a gene family encoding reticulons". Genomics. 51 (1): 98–106. doi:10.1006/geno.1997.5175. PMID 9693037.