RTN1

Reticulon-1 also known as neuroendocrine-specific protein (NSP) is a protein that in humans is encoded by the RTN1 gene.[5][6]

RTN1
Identifiers
Aliases	RTN1, NSP, reticulon 1
External IDs	OMIM: 600865 MGI: 1933947 HomoloGene: 49654 GeneCards: RTN1
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q23.1 Start 59,595,976 bp[1] End 59,870,776 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C3 Start 72,211,752 bp[2] End 72,409,054 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • integral component of membrane • integral component of endoplasmic reticulum membrane • endoplasmic reticulum membrane • membrane • endoplasmic reticulum • Golgi membrane • Golgi apparatus Biological process • neuron differentiation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6252	104001
Ensembl	ENSG00000139970	ENSMUSG00000021087
UniProt	Q16799	Q8K0T0
RefSeq (mRNA)	NM_001243115 NM_021136 NM_206852 NM_206857 NM_001363702	NM_001007596 NM_001286448 NM_153457
RefSeq (protein)	NP_066959 NP_996734 NP_001350631	NP_001007597 NP_001273377 NP_703187
Location (UCSC)	Chr 14: 59.6 – 59.87 Mb	Chr 12: 72.21 – 72.41 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

This gene belongs to the family of reticulon-encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Alternatively spliced transcript variants encoding different isoforms have been identified. Multiple promoters rather than alternative splicing of internal exons seem to be involved in this diversity.[6]

Interactions

RTN1 has been shown to interact with BCL2-like 1[7] and UGCG.[8]

References

1. GRCh38: Ensembl release 89: ENSG00000139970 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021087 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kools PF, Roebroek AJ, Van de Velde HJ, Marynen P, Bullerdiek J, Van de Ven WJ (February 1994). "Regional mapping of the human NSP gene to chromosome region 14q21→q22 by fluorescence in situ hybridization analysis". Cytogenet Cell Genet. 66 (1): 48–50. doi:10.1159/000133662. PMID 8275708.
6. "Entrez Gene: RTN1 reticulon 1".
7. Tagami S, Eguchi Y, Kinoshita M, Takeda M, Tsujimoto Y (November 2000). "A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity". Oncogene. 19 (50): 5736–46. doi:10.1038/sj.onc.1203948. PMID 11126360.
8. Di Sano F, Fazi B, Citro G, Lovat PE, Cesareni G, Piacentini M (July 2003). "Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells". Cancer Res. 63 (14): 3860–5. PMID 12873973.

Further reading

• Senden NH, van de Velde HJ, Broers JL, Timmer ED, Roebroek AJ, van de Ven WJ, Ramaekers FC (1994). "Cluster-10 lung-cancer antibodies recognize NSPs, novel neuro-endocrine proteins associated with membranes of the endoplasmic reticulum". Int. J. Cancer Suppl. 8: 84–8. doi:10.1002/ijc.2910570718. PMID 7515034.
• Roebroek AJ, van de Velde HJ, Van Bokhoven A, Broers JL, Ramaekers FC, Van de Ven WJ (1993). "Cloning and expression of alternative transcripts of a novel neuroendocrine-specific gene and identification of its 135-kDa translational product". J. Biol. Chem. 268 (18): 13439–47. PMID 7685762.
• van de Velde HJ, Roebroek AJ, Senden NH, Ramaekers FC, Van de Ven WJ (1995). "NSP-encoded reticulons, neuroendocrine proteins of a novel gene family associated with membranes of the endoplasmic reticulum". J. Cell Sci. 107 (9): 2403–16. PMID 7844160.
• van de Velde HJ, Senden NH, Roskams TA, Broers JL, Ramaekers FC, Roebroek AJ, Van de Ven WJ (1994). "NSP-encoded reticulons are neuroendocrine markers of a novel category in human lung cancer diagnosis". Cancer Res. 54 (17): 4769–76. PMID 8062278.
• Roebroek AJ, Ayoubi TA, Van de Velde HJ, Schoenmakers EF, Pauli IG, Van de Ven WJ (1997). "Genomic organization of the human NSP gene, prototype of a novel gene family encoding reticulons". Genomics. 32 (2): 191–9. doi:10.1006/geno.1996.0105. PMID 8833145.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Senden NH, Timmer ED, Boers JE, van de Velde HJ, Roebroek AJ, Van de Ven WJ, Broers JL, Ramaekers FC (1996). "Neuroendocrine-specific protein C (NSP-C): subcellular localization and differential expression in relation to NSP-A". Eur. J. Cell Biol. 69 (3): 197–213. PMID 8900485.
• Hens J, Nuydens R, Geerts H, Senden NH, Van de Ven WJ, Roebroek AJ, van de Velde HJ, Ramaekers FC, Broers JL (1998). "Neuronal differentiation is accompanied by NSP-C expression". Cell Tissue Res. 292 (2): 229–37. doi:10.1007/s004410051054. PMID 9560466.
• Tagami S, Eguchi Y, Kinoshita M, Takeda M, Tsujimoto Y (2001). "A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity". Oncogene. 19 (50): 5736–46. doi:10.1038/sj.onc.1203948. PMID 11126360.
• Oertle T, Klinger M, Stuermer CA, Schwab ME (2003). "A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family". FASEB J. 17 (10): 1238–47. CiteSeerX 10.1.1.124.969. doi:10.1096/fj.02-1166hyp. PMID 12832288.
• Di Sano F, Fazi B, Citro G, Lovat PE, Cesareni G, Piacentini M (2003). "Glucosylceramide synthase and its functional interaction with RTN-1C regulate chemotherapeutic-induced apoptosis in neuroepithelioma cells". Cancer Res. 63 (14): 3860–5. PMID 12873973.
• Iwahashi J, Hamada N (2004). "Human reticulon 1-A and 1-B interact with a medium chain of the AP-2 adaptor complex". Cell. Mol. Biol. (Noisy-le-grand). 49 Online Pub: OL467–71. PMID 14995077.
• Hu Y, Fang X, Dunham SM, Prada C, Stachowiak EK, Stachowiak MK (2004). "90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling". J. Biol. Chem. 279 (28): 29325–35. doi:10.1074/jbc.M311144200. PMID 15117958.
• He W, Lu Y, Qahwash I, Hu XY, Chang A, Yan R (2004). "Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation". Nat. Med. 10 (9): 959–65. doi:10.1038/nm1088. PMID 15286784.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Mannan AU, Boehm J, Sauter SM, Rauber A, Byrne PC, Neesen J, Engel W (2007). "Spastin, the most commonly mutated protein in hereditary spastic paraplegia interacts with Reticulon 1 an endoplasmic reticulum protein". Neurogenetics. 7 (2): 93–103. doi:10.1007/s10048-006-0034-4. PMID 16602018.