RSF1

Remodeling and spacing factor 1 is a protein that in humans is encoded by the RSF1 gene.[5][6][7]

RSF1
Identifiers
Aliases	RSF1, HBXAP, RSF-1, XAP8, p325, remodeling and spacing factor 1
External IDs	OMIM: 608522 MGI: 2682305 HomoloGene: 41142 GeneCards: RSF1
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q14.1 Start 77,659,996 bp[1] End 77,821,017 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E1 Start 97,579,889 bp[2] End 97,692,778 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • histone binding • ATPase activity • GO:0001948 protein binding • metal ion binding • histone acetyltransferase activity Cellular component • RSF complex • cell nucleus • nucleoplasm • histone acetyltransferase complex • nuclear chromatin Biological process • positive regulation of transcription, DNA-templated • negative regulation of DNA binding • chromatin remodeling • positive regulation of viral transcription • nucleosome positioning • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • CENP-A containing nucleosome assembly • transcription, DNA-templated • DNA-templated transcription, initiation • nucleosome assembly • chromatin organization • histone acetylation • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51773	233532
Ensembl	ENSG00000048649	ENSMUSG00000035623
UniProt	Q96T23 Q05DG0	n/a
RefSeq (mRNA)	NM_016578	NM_001081267
RefSeq (protein)	NP_057662 NP_057662.3	n/a
Location (UCSC)	Chr 11: 77.66 – 77.82 Mb	Chr 7: 97.58 – 97.69 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

HBXAP is involved in transcription repression, transcription coactivation when associated with hepatitis B virus X protein (HBX), and chromatin remodeling and spacing when associated with SNF2H (MIM 603375).[supplied by OMIM][7]

References

1. GRCh38: Ensembl release 89: ENSG00000048649 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000035623 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shamay M, Barak O, Doitsh G, Ben-Dor I, Shaul Y (Mar 2002). "Hepatitis B virus pX interacts with HBXAP, a PHD finger protein to coactivate transcription". J Biol Chem. 277 (12): 9982–8. doi:10.1074/jbc.M111354200. PMID 11788598.
6. Loyola A, Huang JY, LeRoy G, Hu S, Wang YH, Donnelly RJ, Lane WS, Lee SC, Reinberg D (Sep 2003). "Functional analysis of the subunits of the chromatin assembly factor RSF". Mol Cell Biol. 23 (19): 6759–68. doi:10.1128/MCB.23.19.6759-6768.2003. PMC 193931. PMID 12972596.
7. "Entrez Gene: RSF1 remodeling and spacing factor 1".

Further reading

• Lee TH, Elledge SJ, Butel JS (1995). "Hepatitis B virus X protein interacts with a probable cellular DNA repair protein". J. Virol. 69 (2): 1107–14. PMC 188683. PMID 7815490.
• LeRoy G, Orphanides G, Lane WS, Reinberg D (1998). "Requirement of RSF and FACT for transcription of chromatin templates in vitro". Science. 282 (5395): 1900–4. doi:10.1126/science.282.5395.1900. PMID 9836642.
• Shamay M, Barak O, Shaul Y (2002). "HBXAP, a novel PHD-finger protein, possesses transcription repression activity". Genomics. 79 (4): 523–9. doi:10.1006/geno.2002.6717. PMID 11944984.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096.
• Huang JY, Shen BJ, Tsai WH, Lee SC (2004). "Functional interaction between nuclear matrix-associated HBXAP and NF-kappaB". Exp. Cell Res. 298 (1): 133–43. doi:10.1016/j.yexcr.2004.04.019. PMID 15242768.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Shih IeM, Sheu JJ, Santillan A, et al. (2005). "Amplification of a chromatin remodeling gene, Rsf-1/HBXAP, in ovarian carcinoma". Proc. Natl. Acad. Sci. U.S.A. 102 (39): 14004–9. doi:10.1073/pnas.0504195102. PMC 1236547. PMID 16172393.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.