RRS1

Ribosome biogenesis regulatory protein homolog is a protein that in humans is encoded by the RRS1 gene.[5][6][7]

RRS1
Identifiers
Aliases	RRS1, ribosome biogenesis regulator homolog, ribosome biogenesis regulator 1 homolog
External IDs	OMIM: 618311 MGI: 1929721 HomoloGene: 41014 GeneCards: RRS1
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q13.1 Start 66,429,014 bp[1] End 66,430,733 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 A2|1 2.08 cM Start 9,545,408 bp[2] End 9,547,455 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding • RNA binding • 5S rRNA binding Cellular component • condensed nuclear chromosome • nucleolus • cell nucleus • endoplasmic reticulum • preribosome, large subunit precursor • fibrillar center Biological process • ribosomal large subunit export from nucleus • mitotic metaphase plate congression • ribosome biogenesis • hematopoietic progenitor cell differentiation • endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) • ribosomal large subunit assembly • ribosomal large subunit biogenesis • protein localization to nucleolus • regulation of signal transduction by p53 class mediator Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23212	59014
Ensembl	ENSG00000179041	ENSMUSG00000061024
UniProt	Q15050	Q9CYH6
RefSeq (mRNA)	NM_015169	NM_021511
RefSeq (protein)	NP_055984	NP_067486
Location (UCSC)	Chr 8: 66.43 – 66.43 Mb	Chr 1: 9.55 – 9.55 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000179041 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000061024 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, Tabata S, Ishikawa K, Kawarabayasi Y, Kotani H, et al. (Jul 1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
6. Tsuno A, Miyoshi K, Tsujii R, Miyakawa T, Mizuta K (Mar 2000). "RRS1, a Conserved Essential Gene, Encodes a Novel Regulatory Protein Required for Ribosome Biogenesis in Saccharomyces cerevisiae". Mol Cell Biol. 20 (6): 2066–74. doi:10.1128/MCB.20.6.2066-2074.2000. PMC 110823. PMID 10688653.
7. "Entrez Gene: RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)".

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherl A, Couté Y, Déon C, et al. (2003). "Functional Proteomic Analysis of Human Nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.