RRN3

RNA polymerase I-specific transcription initiation factor RRN3 is an enzyme that in humans is encoded by the RRN3 gene.[5][6][7]

RRN3
Identifiers
Aliases	RRN3, A-270G1.2, TIFIA, RRN3 homolog, RNA polymerase I transcription factor
External IDs	OMIM: 605121 MGI: 1925255 HomoloGene: 39531 GeneCards: RRN3
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16p13.11 Start 15,060,022 bp[1] End 15,094,317 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 A1 Start 13,780,708 bp[2] End 13,814,839 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • RNA polymerase binding • GO:0001187 RNA polymerase I core promoter sequence-specific DNA binding • RNA polymerase I core binding • transcription factor activity, core RNA polymerase I binding Cellular component • nucleolus • nucleoplasm • cell nucleus Biological process • in utero embryonic development • nucleolus organization • positive regulation of neuron projection development • regulation of transcription, DNA-templated • cellular proliferation • negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator • DNA-templated transcription, initiation • regulation of DNA-templated transcription, initiation • positive regulation of transcription, DNA-templated • cytoplasm organization • transcription, DNA-templated • homeostasis of number of cells • transcription initiation from RNA polymerase I promoter • ribosome biogenesis • regulation of transcription from RNA polymerase I promoter • RNA polymerase I transcriptional preinitiation complex assembly Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54700	106298
Ensembl	ENSG00000085721 ENSG00000278494	ENSMUSG00000022682
UniProt	Q9NYV6	B2RS91
RefSeq (mRNA)	NM_001301064 NM_018427	NM_001039521
RefSeq (protein)	NP_001287993 NP_060897	NP_001034610
Location (UCSC)	Chr 16: 15.06 – 15.09 Mb	Chr 16: 13.78 – 13.81 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

RRN3 has been shown to interact with TAF1B.[6]

References

1. ENSG00000278494 GRCh38: Ensembl release 89: ENSG00000085721, ENSG00000278494 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022682 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Moorefield B, Greene EA, Reeder RH (May 2000). "RNA polymerase I transcription factor Rrn3 is functionally conserved between yeast and human". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4724–9. doi:10.1073/pnas.080063997. PMC 18300. PMID 10758157.
6. Miller G, Panov KI, Friedrich JK, Trinkle-Mulcahy L, Lamond AI, Zomerdijk JC (Mar 2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters". EMBO J. 20 (6): 1373–82. doi:10.1093/emboj/20.6.1373. PMC 145519. PMID 11250903.
7. "Entrez Gene: RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Bodem J, Dobreva G, Hoffmann-Rohrer U, Iben S, Zentgraf H, Delius H, Vingron M, Grummt I (2000). "TIF-IA, the factor mediating growth-dependent control of ribosomal RNA synthesis, is the mammalian homolog of yeast Rrn3p". EMBO Rep. 1 (2): 171–5. doi:10.1093/embo-reports/kvd032. PMC 1084264. PMID 11265758.
• Yuan X, Zhao J, Zentgraf H, Hoffmann-Rohrer U, Grummt I (2002). "Multiple interactions between RNA polymerase I, TIF-IA and TAF(I) subunits regulate preinitiation complex assembly at the ribosomal gene promoter". EMBO Rep. 3 (11): 1082–7. doi:10.1093/embo-reports/kvf212. PMC 1307603. PMID 12393749.
• Zhao J, Yuan X, Frödin M, Grummt I (2003). "ERK-dependent phosphorylation of the transcription initiation factor TIF-IA is required for RNA polymerase I transcription and cell growth". Mol. Cell. 11 (2): 405–13. doi:10.1016/S1097-2765(03)00036-4. PMID 12620228.
• Mayer C, Zhao J, Yuan X, Grummt I (2004). "mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability". Genes Dev. 18 (4): 423–34. doi:10.1101/gad.285504. PMC 359396. PMID 15004009.
• Philimonenko VV, Zhao J, Iben S, Dingová H, Kyselá K, Kahle M, Zentgraf H, Hofmann WA, de Lanerolle P, Hozák P, Grummt I (2004). "Nuclear actin and myosin I are required for RNA polymerase I transcription". Nat. Cell Biol. 6 (12): 1165–72. doi:10.1038/ncb1190. PMID 15558034.