RREB1

Ras-responsive element-binding protein 1 is a protein that in humans is encoded by the RREB1 gene.[5][6][7]

RREB1
Identifiers
AliasesRREB1, FINB, HNT, LZ321, RREB-1, Zep-1, ras responsive element binding protein 1
External IDsOMIM: 602209 MGI: 2443664 HomoloGene: 2218 GeneCards: RREB1
Gene location (Human)
Chr.Chromosome 6 (human)[1]
Band6p24.3Start7,107,597 bp[1]
End7,251,980 bp[1]
RNA expression pattern




More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

6239

68750

Ensembl

ENSG00000124782

ENSMUSG00000039087

UniProt

Q92766

Q3UH06

RefSeq (mRNA)

NM_001003698
NM_001003699
NM_001003700
NM_001168344
NM_002955

NM_001013392
NM_001039188
NM_001177868
NM_001177869
NM_026830

RefSeq (protein)

NP_001034277
NP_001171339
NP_001171340
NP_081106

Location (UCSC)Chr 6: 7.11 – 7.25 MbChr 13: 37.78 – 37.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Clinical significance

Mutations in RREB1 are associated to type 2 diabetes associated end-stage kidney disease.[8]

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References

  1. GRCh38: Ensembl release 89: ENSG00000124782 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000039087 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Thiagalingam A, Lengauer C, Baylin SB, Nelkin BD (Jan 1998). "RREB1, a ras responsive element binding protein, maps to human chromosome 6p25". Genomics. 45 (3): 630–632. doi:10.1006/geno.1997.5001. PMID 9367691.
  6. Melani M, Simpson KJ, Brugge JS, Montell D (Apr 2008). "Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1". Curr Biol. 18 (7): 532–537. doi:10.1016/j.cub.2008.03.024. PMID 18394891.
  7. "Entrez Gene: RREB1 ras responsive element binding protein 1".
  8. Bonomo, J. A.; Guan, M; Ng, M. C.; Palmer, N. D.; Hicks, P. J.; Keaton, J. M.; Lea, J. P.; Langefeld, C. D.; Freedman, B. I.; Bowden, D. W. (2014). "The ras responsive transcription factor RREB1 is a novel candidate gene for type 2 diabetes associated end-stage kidney disease". Human Molecular Genetics. 23 (24): 6441–7. doi:10.1093/hmg/ddu362. PMC 4240197. PMID 25027322.

Further reading


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