ROBO4

Roundabout homolog 4 is a protein that in humans is encoded by the ROBO4 gene.[5][6]

ROBO4
Identifiers
Aliases	ROBO4, ECSM4, MRB, roundabout guidance receptor 4, AOVD3
External IDs	OMIM: 607528 MGI: 1921394 HomoloGene: 10397 GeneCards: ROBO4
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q24.2 Start 124,883,691 bp[1] End 124,898,500 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A4 Start 37,401,897 bp[2] End 37,415,115 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • receptor activity • signaling receptor activity • protein binding involved in cell-cell adhesion Cellular component • integral component of membrane • extracellular exosome • cell membrane • axon Biological process • multicellular organism development • cell differentiation • regulation of cell migration • angiogenesis • homophilic cell adhesion via plasma membrane adhesion molecules • axon guidance • dendrite self-avoidance Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54538	74144
Ensembl	ENSG00000154133	ENSMUSG00000032125
UniProt	Q8WZ75	Q8C310
RefSeq (mRNA)	NM_001301088 NM_019055	NM_028783 NM_001309390
RefSeq (protein)	NP_001288017 NP_061928	NP_001296319 NP_083059
Location (UCSC)	Chr 11: 124.88 – 124.9 Mb	Chr 9: 37.4 – 37.42 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000154133 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032125 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Huminiecki L, Bicknell R (November 2000). "In silico cloning of novel endothelial-specific genes". Genome Research. 10 (11): 1796–806. doi:10.1101/gr.150700. PMC 310981. PMID 11076864.
6. "Entrez Gene: ROBO4 roundabout homolog 4, magic roundabout (Drosophila)".

Further reading

• Schmucker D (September 2003). "Downstream of guidance receptors: entering the baroque period of axon guidance signaling". Neuron. 40 (1): 4–6. doi:10.1016/S0896-6273(03)00603-2. PMID 14527427.
• Huminiecki L, Gorn M, Suchting S, Poulsom R, Bicknell R (April 2002). "Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis". Genomics. 79 (4): 547–52. doi:10.1006/geno.2002.6745. PMID 11944987.
• Park KW, Morrison CM, Sorensen LK, Jones CA, Rao Y, Chien CB, Wu JY, Urness LD, Li DY (September 2003). "Robo4 is a vascular-specific receptor that inhibits endothelial migration". Developmental Biology. 261 (1): 251–67. doi:10.1016/S0012-1606(03)00258-6. PMID 12941633.
• Bedell VM, Yeo SY, Park KW, Chung J, Seth P, Shivalingappa V, Zhao J, Obara T, Sukhatme VP, Drummond IA, Li DY, Ramchandran R (May 2005). "roundabout4 is essential for angiogenesis in vivo". Proceedings of the National Academy of Sciences of the United States of America. 102 (18): 6373–8. Bibcode:2005PNAS..102.6373B. doi:10.1073/pnas.0408318102. PMC 1088354. PMID 15849270.
• Seth P, Lin Y, Hanai J, Shivalingappa V, Duyao MP, Sukhatme VP (July 2005). "Magic roundabout, a tumor endothelial marker: expression and signaling". Biochemical and Biophysical Research Communications. 332 (2): 533–41. doi:10.1016/j.bbrc.2005.03.250. PMID 15894287.
• Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". Journal of Proteome Research. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
• Gröne J, Doebler O, Loddenkemper C, Hotz B, Buhr HJ, Bhargava S (June 2006). "Robo1/Robo4: differential expression of angiogenic markers in colorectal cancer". Oncology Reports. 15 (6): 1437–43. doi:10.3892/or.15.6.1437. PMID 16685377.
• Okada Y, Yano K, Jin E, Funahashi N, Kitayama M, Doi T, Spokes K, Beeler DL, Shih SC, Okada H, Danilov TA, Maynard E, Minami T, Oettgen P, Aird WC (June 2007). "A three-kilobase fragment of the human Robo4 promoter directs cell type-specific expression in endothelium". Circulation Research. 100 (12): 1712–22. doi:10.1161/01.RES.0000269779.10644.dc. PMID 17495228.