RNF25

E3 ubiquitin-protein ligase RNF25 is an enzyme that in humans is encoded by the RNF25 gene.[5][6]

RNF25
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRNF25, AO7, ring finger protein 25
External IDsOMIM: 616014 MGI: 1890215 HomoloGene: 11193 GeneCards: RNF25
Gene location (Human)
Chr.Chromosome 2 (human)[1]
Band2q35Start218,663,892 bp[1]
End218,672,002 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

64320

57751

Ensembl

ENSG00000163481

ENSMUSG00000026171

UniProt

Q96BH1

Q9QZR0

RefSeq (mRNA)

NM_022453

NM_021313
NM_001305230

RefSeq (protein)

NP_071898

NP_001292159
NP_067288

Location (UCSC)Chr 2: 218.66 – 218.67 MbChr 1: 74.59 – 74.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The protein encoded by this gene contains a RING finger motif. The mouse counterpart of this protein has been shown to interact with Rela, the p65 subunit of NF-kappaB (NF-κB), and modulate NF-κB-mediated transcription activity. The mouse protein also binds ubiquitin-conjugating enzymes (E2s) and is a substrate for E2-dependent ubiquitination.[6]

Interactions

RNF25 has been shown to interact with RELA.[5]

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References
  1. GRCh38: Ensembl release 89: ENSG00000163481 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026171 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Asamitsu K, Tetsuka T, Kanazawa S, Okamoto T (Jul 2003). "RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit". J. Biol. Chem. 278 (29): 26879–87. doi:10.1074/jbc.M211831200. PMID 12748188.
  6. "Entrez Gene: RNF25 ring finger protein 25".

Further reading
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Lorick KL, Jensen JP, Fang S, Ong AM, Hatakeyama S, Weissman AM (1999). "RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11364–9. doi:10.1073/pnas.96.20.11364. PMC 18039. PMID 10500182.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.


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