RNF20

E3 ubiquitin-protein ligase BRE1A is an enzyme that in humans is encoded by the RNF20 gene.[5][6][7][8][9]

RNF20
Identifiers
Aliases	RNF20, BRE1, BRE1A, hBRE1, ring finger protein 20
External IDs	OMIM: 607699 MGI: 1925927 HomoloGene: 5571 GeneCards: RNF20
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q31.1 Start 101,533,853 bp[1] End 101,563,344 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 B1 Start 49,632,006 bp[2] End 49,656,887 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001105 transcription coactivator activity • histone binding • p53 binding • chromatin binding • metal ion binding • mRNA 3'-UTR binding • GO:0001948 protein binding • ubiquitin protein ligase binding • transferase activity • ubiquitin-protein transferase activity Cellular component • ubiquitin ligase complex • HULC complex • nucleolus • cell nucleus • nucleoplasm Biological process • regulation of transcription, DNA-templated • negative regulation of mRNA polyadenylation • positive regulation of histone methylation • ubiquitin-dependent protein catabolic process • protein polyubiquitination • positive regulation of transcription, DNA-templated • negative regulation of cell migration • regulation of mitotic cell cycle • histone H2B ubiquitination • positive regulation of histone H2B ubiquitination • histone ubiquitination • protein ubiquitination • histone monoubiquitination • chromatin organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	56254	109331
Ensembl	ENSG00000155827	ENSMUSG00000028309
UniProt	Q5VTR2	Q5DTM8
RefSeq (mRNA)	NM_019592	NM_001163263 NM_182999 NM_001356401
RefSeq (protein)	NP_062538	NP_001156735 NP_892044 NP_001343330
Location (UCSC)	Chr 9: 101.53 – 101.56 Mb	Chr 4: 49.63 – 49.66 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. Yeast BRE1 is a ubiquitin ligase required for the ubiquitination of histone H2B and the methylation of histone H3.[9]

See also

• RING finger domain

References

1. GRCh38: Ensembl release 89: ENSG00000155827 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028309 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kim J, Hake SB, Roeder RG (Dec 2005). "The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions". Mol Cell. 20 (5): 759–70. doi:10.1016/j.molcel.2005.11.012. PMID 16337599.
6. Wood A, Schneider J, Dover J, Johnston M, Shilatifard A (Sep 2003). "The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p". J Biol Chem. 278 (37): 34739–42. doi:10.1074/jbc.C300269200. PMID 12876294.
7. Shema E, Tirosh I, Aylon Y, Huang J, Ye C, Moskovits N, Raver-Shapira N, Minsky N, Pirngruber J, Tarcic G, Hublarova P, Moyal L, Gana-Weisz M, Shiloh Y, Yarden Y, Johnsen SA, Vojtesek B, Berger SL, Oren M (Oct 2008). "The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression". Genes Dev. 22 (19): 2664–76. doi:10.1101/gad.1703008. PMC 2559905. PMID 18832071.
8. Liu Z, Oh SM, Okada M, Liu X, Cheng D, Peng J, Brat DJ, Sun SY, Zhou W, Gu W, Ye K (Feb 2009). "Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor". Mol Biol Cell. 20 (3): 757–68. doi:10.1091/mbc.E08-09-0983. PMC 2633391. PMID 19037095.
9. "Entrez Gene: RNF20 ring finger protein 20".

Further reading

• Lossos IS, Alizadeh AA, Eisen MB, et al. (2000). "Ongoing immunoglobulin somatic mutation in germinal center B cell-like but not in activated B cell-like diffuse large cell lymphomas". Proc. Natl. Acad. Sci. U.S.A. 97 (18): 10209–13. doi:10.1073/pnas.180316097. PMC 27813. PMID 10954754.
• Slachta CA, Jeevanandam V, Goldman B, et al. (2000). "Coronary arteries from human cardiac allografts with chronic rejection contain oligoclonal T cells: persistence of identical clonally expanded TCR transcripts from the early post-transplantation period (endomyocardial biopsies) to chronic rejection (coronary arteries)". J. Immunol. 165 (6): 3469–83. doi:10.4049/jimmunol.165.6.3469. PMID 10975868.
• Lee J, Monson NL, Lipsky PE (2001). "The V lambda J lambda repertoire in human fetal spleen: evidence for positive selection and extensive receptor editing". J. Immunol. 165 (11): 6322–33. doi:10.4049/jimmunol.165.11.6322. PMID 11086069.
• Rowley AH, Shulman ST, Spike BT, et al. (2001). "Oligoclonal IgA response in the vascular wall in acute Kawasaki disease". J. Immunol. 166 (2): 1334–43. doi:10.4049/jimmunol.166.2.1334. PMID 11145718.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hwang WW, Venkatasubrahmanyam S, Ianculescu AG, et al. (2003). "A conserved RING finger protein required for histone H2B monoubiquitination and cell size control". Mol. Cell. 11 (1): 261–6. doi:10.1016/S1097-2765(02)00826-2. PMID 12535538.
• Wood A, Krogan NJ, Dover J, et al. (2003). "Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter". Mol. Cell. 11 (1): 267–74. doi:10.1016/S1097-2765(02)00802-X. PMID 12535539.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Zhu B, Zheng Y, Pham AD, et al. (2006). "Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation". Mol. Cell. 20 (4): 601–11. doi:10.1016/j.molcel.2005.09.025. PMID 16307923.

External links

• RNF20+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)