RNF20

E3 ubiquitin-protein ligase BRE1A is an enzyme that in humans is encoded by the RNF20 gene.[5][6][7][8][9]

RNF20
Identifiers
AliasesRNF20, BRE1, BRE1A, hBRE1, ring finger protein 20
External IDsOMIM: 607699 MGI: 1925927 HomoloGene: 5571 GeneCards: RNF20
Gene location (Human)
Chr.Chromosome 9 (human)[1]
Band9q31.1Start101,533,853 bp[1]
End101,563,344 bp[1]
RNA expression pattern
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez

56254

109331

Ensembl

ENSG00000155827

ENSMUSG00000028309

UniProt

Q5VTR2

Q5DTM8

RefSeq (mRNA)

NM_019592

NM_001163263
NM_182999
NM_001356401

RefSeq (protein)

NP_062538

NP_001156735
NP_892044
NP_001343330

Location (UCSC)Chr 9: 101.53 – 101.56 MbChr 4: 49.63 – 49.66 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. Yeast BRE1 is a ubiquitin ligase required for the ubiquitination of histone H2B and the methylation of histone H3.[9]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000155827 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028309 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kim J, Hake SB, Roeder RG (Dec 2005). "The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions". Mol Cell. 20 (5): 759–70. doi:10.1016/j.molcel.2005.11.012. PMID 16337599.
  6. Wood A, Schneider J, Dover J, Johnston M, Shilatifard A (Sep 2003). "The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p". J Biol Chem. 278 (37): 34739–42. doi:10.1074/jbc.C300269200. PMID 12876294.
  7. Shema E, Tirosh I, Aylon Y, Huang J, Ye C, Moskovits N, Raver-Shapira N, Minsky N, Pirngruber J, Tarcic G, Hublarova P, Moyal L, Gana-Weisz M, Shiloh Y, Yarden Y, Johnsen SA, Vojtesek B, Berger SL, Oren M (Oct 2008). "The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression". Genes Dev. 22 (19): 2664–76. doi:10.1101/gad.1703008. PMC 2559905. PMID 18832071.
  8. Liu Z, Oh SM, Okada M, Liu X, Cheng D, Peng J, Brat DJ, Sun SY, Zhou W, Gu W, Ye K (Feb 2009). "Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor". Mol Biol Cell. 20 (3): 757–68. doi:10.1091/mbc.E08-09-0983. PMC 2633391. PMID 19037095.
  9. "Entrez Gene: RNF20 ring finger protein 20".

Further reading


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