RNF13

RING finger protein 13 is a protein that in humans is encoded by the RNF13 gene.[5]

RNF13
Identifiers
Aliases	RNF13, RZF, ring finger protein 13, EIEE73
External IDs	OMIM: 609247 MGI: 1346341 HomoloGene: 13493 GeneCards: RNF13
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q25.1 Start 149,812,708 bp[1] End 149,962,139 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 D Start 57,736,062 bp[2] End 57,835,233 bp[2]
Gene ontology Molecular function • metal ion binding • GO:0001948 protein binding • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • ubiquitin-protein transferase activity • transferase activity • zinc ion binding Cellular component • integral component of membrane • lysosomal membrane • Golgi membrane • nuclear inner membrane • endosome • lysosome • Golgi apparatus • endoplasmic reticulum membrane • endoplasmic reticulum • late endosome membrane • cell nucleus • membrane • nucleoplasm • cytosol • intracellular membrane-bounded organelle Biological process • protein ubiquitination • protein autoubiquitination • ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	11342	24017
Ensembl	ENSG00000082996	ENSMUSG00000036503
UniProt	O43567	O54965
RefSeq (mRNA)	NM_007282 NM_183381 NM_183382 NM_183383 NM_183384 NM_001378285 NM_001378286 NM_001378287 NM_001378288 NM_001378289 NM_001378290 NM_001378291	NM_001113413 NM_011883 NM_001304454 NM_001304456 NM_001357080
RefSeq (protein)	NP_009213 NP_899237 NP_899239 NP_001365214 NP_001365215 NP_001365216 NP_001365217 NP_001365218 NP_001365219 NP_001365220	NP_001106884 NP_001291383 NP_001291385 NP_036013 NP_001344009
Location (UCSC)	Chr 3: 149.81 – 149.96 Mb	Chr 3: 57.74 – 57.84 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. The specific function of this gene has not yet been determined. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000082996 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036503 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: RNF13 ring finger protein 13".

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Wesselkamper SC, McDowell SA, Medvedovic M, et al. (2006). "The role of metallothionein in the pathogenesis of acute lung injury". Am. J. Respir. Cell Mol. Biol. 34 (1): 73–82. doi:10.1165/rcmb.2005-0248OC. PMC 2644192. PMID 16166738.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Tranque P, Crossin KL, Cirelli C, et al. (1996). "Identification and characterization of a RING zinc finger gene (C-RZF) expressed in chicken embryo cells". Proc. Natl. Acad. Sci. U.S.A. 93 (7): 3105–9. doi:10.1073/pnas.93.7.3105. PMC 39769. PMID 8610176.