RNF122

RING finger protein 122 is a protein that in humans is encoded by the RNF122 gene.[5]

RNF122
Identifiers
Aliases	RNF122, ring finger protein 122
External IDs	MGI: 1916117 HomoloGene: 11717 GeneCards: RNF122
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p12 Start 33,547,754 bp[1] End 33,567,128 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 A3 Start 31,111,820 bp[2] End 31,131,482 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity • metal ion binding • GO:0001948 protein binding Cellular component • integral component of membrane • Golgi apparatus • membrane • endoplasmic reticulum • endomembrane system • cytoplasm Biological process • proteasome-mediated ubiquitin-dependent protein catabolic process • protein polyubiquitination • protein ubiquitination • negative regulation of mitochondrial membrane potential • positive regulation of apoptotic process • protein autoubiquitination Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	79845	68867
Ensembl	ENSG00000133874	ENSMUSG00000039328
UniProt	Q9H9V4	Q8BP31
RefSeq (mRNA)	NM_024787	NM_175136 NM_001368373 NM_001368374 NM_001368375
RefSeq (protein)	NP_079063	NP_780345 NP_001355302 NP_001355303 NP_001355304
Location (UCSC)	Chr 8: 33.55 – 33.57 Mb	Chr 8: 31.11 – 31.13 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions.[5]

References

1. GRCh38: Ensembl release 89: ENSG00000133874 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039328 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: RNF122 ring finger protein 122".

Further reading

• Koyama K, Sudo K, Nakamura Y (1995). "Isolation of 115 human chromosome 8-specific expressed-sequence tags by exon amplification". Genomics. 26 (2): 245–53. doi:10.1016/0888-7543(95)80207-3. PMID 7601449.
• Saurin AJ, Borden KL, Boddy MN, Freemont PS (1996). "Does this have a familiar RING?". Trends Biochem. Sci. 21 (6): 208–14. doi:10.1016/s0968-0004(96)80017-x. PMID 8744354.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Wang L, Gao X, Gao P, et al. (2006). "Cell-based screening and validation of human novel genes associated with cell viability". Journal of Biomolecular Screening. 11 (4): 369–76. doi:10.1177/1087057106286654. PMID 16751333.
• Wang L, Shi TP, Wang L, et al. (2006). "[Cloning, expression and subcellular localization of a novel human gene-RNF122]". Beijing da Xue Xue Bao. 38 (3): 239–43. PMID 16778963.