RNF10

Function

The protein encoded by this gene contains a ring finger motif, which is known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. EST data suggests the existence of multiple alternatively spliced transcript variants, however, their full length nature is not known.[5]

Model organisms

Model organisms have been used in the study of RNF10 function. A conditional knockout mouse line, called Rnf10tm1a(KOMP)Wtsi[14][15] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[16][17][18]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[12][19] Twenty two tests were carried out on mutant mice and five significant abnormalities were observed.[12] Homozygous mutant animals displayed increased chromosomal stability in a micronucleus test. Females also had increased body weight, an increased amount of total body fat and an abnormal complete blood count. Males additionally displayed an increase in eating behavior.[12]

gollark: Maybe. On the one hand I at least like to think I'm vaguely better than average at actually paying attention to explanations for things and won't just immediately consign them to "outgroup → bad" or "not convention → bad". On the other hand probably most people think that since people are bad at comparing things. On the third hand, which I totally have, the alternative is to just assume people doing things are probably right, which seems wrong.
gollark: No, which is why I said I didn't care that much.
gollark: > that might be valid but itS' also an easy to abuse excuse to dislike almost anything> because you can always say that you don't see the pointThis is typically why people explain things.
gollark: I don't care a huge amount either way, but it's vaguely weird.
gollark: I'm against change which isn't particularly useful-seeming and/or basically without notice.

References
  1. GRCh38: Ensembl release 89: ENSG00000022840 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000041740 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: RNF10 ring finger protein 10".
  6. "Body weight data for Rnf10". Wellcome Trust Sanger Institute.
  7. "Indirect calorimetry data for Rnf10". Wellcome Trust Sanger Institute.
  8. "DEXA data for Rnf10". Wellcome Trust Sanger Institute.
  9. "Haematology data for Rnf10". Wellcome Trust Sanger Institute.
  10. "Salmonella infection data for Rnf10". Wellcome Trust Sanger Institute.
  11. "Citrobacter infection data for Rnf10". Wellcome Trust Sanger Institute.
  12. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  13. Mouse Resources Portal, Wellcome Trust Sanger Institute.
  14. "International Knockout Mouse Consortium".
  15. "Mouse Genome Informatics".
  16. Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  17. Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  18. Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  19. van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.

Further reading
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