RNASE6

RNASE6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4X09
Identifiers
Aliases	RNASE6, RAD1, RNS6, RNasek6, ribonuclease A family member k6
External IDs	OMIM: 601981 MGI: 1925666 HomoloGene: 4102 GeneCards: RNASE6
Gene location (Human)
Chr.	Chromosome 14 (human)[1]
End	20,782,467 bp[1]
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)[2]
End	51,132,187 bp[2]
Gene ontology
Molecular function	• nuclease activity; • endonuclease activity; • hydrolase activity; • nucleic acid binding; • ribonuclease activity;
Cellular component	• extracellular region; • extracellular; • intracellular; • cytoplasmic vesicle; • lysosome;
Biological process	• defense response; • RNA catabolic process; • antimicrobial humoral response; • antibacterial humoral response; • innate immune system; • defense response to virus; • antimicrobial humoral immune response mediated by antimicrobial peptide; • RNA phosphodiester bond hydrolysis; • defense response to bacterium; • nucleic acid phosphodiester bond hydrolysis;
	Sources:Amigo / QuickGO
Orthologs
	6039
	78416
	ENSG00000169413
	ENSMUSG00000021880
	Q93091; Q6IB39
	Q9D244
	NM_005615
	NM_030098; NM_001360117
	NP_005606; NP_005606.1
	NP_084374; NP_001347046
	Wikidata
View/Edit Human	View/Edit Mouse

Ribonuclease A family member k6 is a protein that in humans is encoded by the RNASE6 gene. [5]

Function

The protein encoded by this gene is a member of the ribonuclease A superfamily and functions in the urinary tract. The protein has broad-spectrum antimicrobial activity against pathogenic bacteria. [provided by RefSeq, Nov 2014].

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References

GRCh38: Ensembl release 89: ENSG00000169413 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000021880 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: Ribonuclease A family member k6". Retrieved 2018-02-21.

Becknell B, Eichler TE, Beceiro S, Li B, Easterling RS, Carpenter AR, James CL, McHugh KM, Hains DS, Partida-Sanchez S, Spencer JD (January 2015). "Ribonucleases 6 and 7 have antimicrobial function in the human and murine urinary tract". Kidney Int. 87 (1): 151–61. doi:10.1038/ki.2014.268. PMC 4281292. PMID 25075772.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000169413 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021880 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Ribonuclease A family member k6". Retrieved 2018-02-21.

RNASE6

Function

References

Further reading