RNA-OUT
RNA-OUT is a non-coding RNA that is antisense to the RNA-IN non-coding RNA. Transposition of insertion sequence IS10 is regulated by an anti-sense RNA which inhibits transposase expression when IS10 is present in multiple copies per cell. IS10 antisense pairing is facilitated by the RNA-binding protein, Hfq. RNA-OUT consists of a stem-loop domain topped by a flexibly paired loop; the 5′ end of the target molecule, RNA-IN, is complementary to the top of the loop, and complementarity extends for 35 nucleotides down one side of RNA-OUT.[1]
| RNA-OUT | |
|---|---|
 Predicted secondary structure and sequence conservation of RNA-OUT | |
| Identifiers | |
| Symbol | RNA-OUT |
| Rfam | RF00240 |
| Other data | |
| RNA type | Gene; antisense |
| Domain(s) | Bacteria |
| SO | 0000644 |
| PDB structures | PDBe |
References
- Kittle JD, Simons RW, Lee J, Kleckner N (December 1989). "Insertion sequence IS10 anti-sense pairing initiates by an interaction between the 5′ end of the target RNA and a loop in the anti-sense RNA". Journal of Molecular Biology. 210 (3): 561–572. doi:10.1016/0022-2836(89)90132-0. PMID 2482367.
External links
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