RMBase (RNA Modification Base)
RMBase (RNA Modification Base) [1][2] is designed for decoding the landscape of RNA modifications identified from high-throughput sequencing data (MeRIP-seq, m6A-seq, miCLIP, m6A-CLIP, Pseudo-seq, Ψ-seq, CeU-seq, Aza-IP, RiboMeth-seq). It contains ~124200 N6-Methyladenosines (m6A), ~9500 pseudouridine (Ψ) modifications, ~1000 5-methylcytosine (m5C) modifications, ~1210 2′-O-methylations (2′-O-Me) and ~3130 other types of RNA modifications. RMBase demonstrated thousands of RNA modifications located within mRNAs, regulatory ncRNAs (e.g. lncRNAs, miRNAs, pseudogenes, circRNAs, snoRNAs, tRNAs), miRNA target sites and disease-related SNPs.
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| Content | |
| Description | decoding the landscape of RNA modifications identified from high-throughput sequencing datasets. |
| Contact | |
| Research center | Sun Yat-sen University |
| Laboratory | Key Laboratory of Gene Engineering of the Ministry of Education |
| Authors | Jian-Hua Yang |
| Primary citation | Sun & al. (2015)[1] |
| Release date | 2010 |
| Access | |
| Website | http://rna.sysu.edu.cn/rmbase/ |
See also
- RNA modification database
- RNA modification
References
- Sun, WJ; Li, JH; Liu, S; Wu, J; Zhou, H; Qu, LH; Yang, JH (11 October 2015). "RMBase: a resource for decoding the landscape of RNA modifications from high-throughput sequencing data". Nucleic Acids Research. 44: gkv1036. doi:10.1093/nar/gkv1036. PMC 4702777. PMID 26464443.
- Xuan, JJ; Sun, WJ; Lin, PH; Zhou, KR; Liu, S; Zheng, LL; Qu, LH; Yang, JH (4 January 2018). "RMBase v2.0: deciphering the map of RNA modifications from epitranscriptome sequencing data". Nucleic Acids Research. 46 (D1): D327–D334. doi:10.1093/nar/gkx934. PMC 5753293. PMID 29040692.
External links
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