RINT1

RINT1
Identifiers
Aliases	RINT1, RINT-1, RAD50 interactor 1, ILFS3
External IDs	OMIM: 610089 MGI: 1916233 HomoloGene: 11070 GeneCards: RINT1
Gene location (Human)
Chr.	Chromosome 7 (human)[1]
End	105,567,677 bp[1]
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)[2]
End	23,820,369 bp[2]
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• GO:0001948 protein binding;
Cellular component	• cytoplasm; • Dsl1/NZR complex; • endoplasmic reticulum membrane; • endoplasmic reticulum; • membrane; • cytosol;
Biological process	• protein transport; • cell cycle; • regulation of signal transduction involved in mitotic G2 DNA damage checkpoint; • regulation of ER to Golgi vesicle-mediated transport; • Golgi vesicle transport; • vesicle-mediated transport; • retrograde vesicle-mediated transport, Golgi to ER; • Golgi organization;
	Sources:Amigo / QuickGO
Orthologs
	60561
	72772
	ENSG00000135249
	ENSMUSG00000028999
	Q6NUQ1
	Q8BZ36
	NM_021930; NM_001346599; NM_001346600; NM_001346601; NM_001346603
	NM_177323; NM_001310467
	NP_001333528; NP_001333529; NP_001333530; NP_001333532; NP_068749
	NP_001297396; NP_796297
	Wikidata
View/Edit Human	View/Edit Mouse

RAD50-interacting protein 1 is a protein that in humans is encoded by the RINT1 gene.[5][6][7]

Interactions

RINT1 has been shown to interact with Rad50[5] and ZW10.[6]

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References

GRCh38: Ensembl release 89: ENSG00000135249 - Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000028999 - Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
Xiao J, Liu CC, Chen PL, Lee WH (Mar 2001). "RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G(2)/M checkpoint control". J Biol Chem. 276 (9): 6105–11. doi:10.1074/jbc.M008893200. PMID 11096100.
Hirose H, Arasaki K, Dohmae N, Takio K, Hatsuzawa K, Nagahama M, Tani K, Yamamoto A, Tohyama M, Tagaya M (Mar 2004). "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi". EMBO J. 23 (6): 1267–78. doi:10.1038/sj.emboj.7600135. PMC 381410. PMID 15029241.
"Entrez Gene: RINT1 RAD50 interactor 1".

"Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Nakajima K, Hirose H, Taniguchi M, et al. (2005). "Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion". EMBO J. 23 (16): 3216–26. doi:10.1038/sj.emboj.7600333. PMC 514507. PMID 15272311.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Arasaki K, Taniguchi M, Tani K, Tagaya M (2006). "RINT-1 Regulates the Localization and Entry of ZW10 to the Syntaxin 18 Complex". Mol. Biol. Cell. 17 (6): 2780–8. doi:10.1091/mbc.E05-10-0973. PMC 1474792. PMID 16571679.
Kong LJ, Meloni AR, Nevins JR (2006). "The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1". Mol. Cell. 22 (1): 63–71. doi:10.1016/j.molcel.2006.02.016. PMID 16600870.
Lin X, Liu CC, Gao Q, et al. (2007). "RINT-1 Serves as a Tumor Suppressor and Maintains Golgi Dynamics and Centrosome Integrity for Cell Survival". Mol. Cell. Biol. 27 (13): 4905–16. doi:10.1128/MCB.02396-06. PMC 1951495. PMID 17470549.
Sun Y, Shestakova A, Hunt L, et al. (2007). "Rab6 Regulates Both ZW10/RINT-1– and Conserved Oligomeric Golgi Complex-dependent Golgi Trafficking and Homeostasis". Mol. Biol. Cell. 18 (10): 4129–42. doi:10.1091/mbc.E07-01-0080. PMC 1995728. PMID 17699596.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135249 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028999 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11096100-5] Xiao J, Liu CC, Chen PL, Lee WH (Mar 2001). "RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G(2)/M checkpoint control". J Biol Chem. 276 (9): 6105–11. doi:10.1074/jbc.M008893200. PMID 11096100.

[pmid15029241-6] Hirose H, Arasaki K, Dohmae N, Takio K, Hatsuzawa K, Nagahama M, Tani K, Yamamoto A, Tohyama M, Tagaya M (Mar 2004). "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi". EMBO J. 23 (6): 1267–78. doi:10.1038/sj.emboj.7600135. PMC 381410. PMID 15029241.

[entrez-7] "Entrez Gene: RINT1 RAD50 interactor 1".

RINT1

Interactions

References

Further reading