RINT1

RAD50-interacting protein 1 is a protein that in humans is encoded by the RINT1 gene.[5][6][7]

RINT1
Identifiers
Aliases	RINT1, RINT-1, RAD50 interactor 1, ILFS3
External IDs	OMIM: 610089 MGI: 1916233 HomoloGene: 11070 GeneCards: RINT1
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.3 Start 105,532,169 bp[1] End 105,567,677 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 A3 Start 23,787,711 bp[2] End 23,820,369 bp[2]
RNA expression pattern More reference expression data
Gene ontology Molecular function • GO:0001948 protein binding Cellular component • cytoplasm • Dsl1/NZR complex • endoplasmic reticulum membrane • endoplasmic reticulum • membrane • cytosol Biological process • protein transport • cell cycle • regulation of signal transduction involved in mitotic G2 DNA damage checkpoint • regulation of ER to Golgi vesicle-mediated transport • Golgi vesicle transport • vesicle-mediated transport • retrograde vesicle-mediated transport, Golgi to ER • Golgi organization Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	60561	72772
Ensembl	ENSG00000135249	ENSMUSG00000028999
UniProt	Q6NUQ1	Q8BZ36
RefSeq (mRNA)	NM_021930 NM_001346599 NM_001346600 NM_001346601 NM_001346603	NM_177323 NM_001310467
RefSeq (protein)	NP_001333528 NP_001333529 NP_001333530 NP_001333532 NP_068749	NP_001297396 NP_796297
Location (UCSC)	Chr 7: 105.53 – 105.57 Mb	Chr 5: 23.79 – 23.82 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

RINT1 has been shown to interact with Rad50[5] and ZW10.[6]

References

1. GRCh38: Ensembl release 89: ENSG00000135249 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028999 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Xiao J, Liu CC, Chen PL, Lee WH (Mar 2001). "RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G(2)/M checkpoint control". J Biol Chem. 276 (9): 6105–11. doi:10.1074/jbc.M008893200. PMID 11096100.
6. Hirose H, Arasaki K, Dohmae N, Takio K, Hatsuzawa K, Nagahama M, Tani K, Yamamoto A, Tohyama M, Tagaya M (Mar 2004). "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi". EMBO J. 23 (6): 1267–78. doi:10.1038/sj.emboj.7600135. PMC 381410. PMID 15029241.
7. "Entrez Gene: RINT1 RAD50 interactor 1".

Further reading

• "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Nakajima K, Hirose H, Taniguchi M, et al. (2005). "Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion". EMBO J. 23 (16): 3216–26. doi:10.1038/sj.emboj.7600333. PMC 514507. PMID 15272311.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Arasaki K, Taniguchi M, Tani K, Tagaya M (2006). "RINT-1 Regulates the Localization and Entry of ZW10 to the Syntaxin 18 Complex". Mol. Biol. Cell. 17 (6): 2780–8. doi:10.1091/mbc.E05-10-0973. PMC 1474792. PMID 16571679.
• Kong LJ, Meloni AR, Nevins JR (2006). "The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1". Mol. Cell. 22 (1): 63–71. doi:10.1016/j.molcel.2006.02.016. PMID 16600870.
• Lin X, Liu CC, Gao Q, et al. (2007). "RINT-1 Serves as a Tumor Suppressor and Maintains Golgi Dynamics and Centrosome Integrity for Cell Survival". Mol. Cell. Biol. 27 (13): 4905–16. doi:10.1128/MCB.02396-06. PMC 1951495. PMID 17470549.
• Sun Y, Shestakova A, Hunt L, et al. (2007). "Rab6 Regulates Both ZW10/RINT-1– and Conserved Oligomeric Golgi Complex-dependent Golgi Trafficking and Homeostasis". Mol. Biol. Cell. 18 (10): 4129–42. doi:10.1091/mbc.E07-01-0080. PMC 1995728. PMID 17699596.